INT233556

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Clu) extracellular space (Clu) cell death (Clu)
extracellular region (Clu) endoplasmic reticulum (Clu) nucleus (Clu)
Anatomy Link Frequency
MCF-7 2
ventral lobe 2
Clu (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 30.72 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 124 99.40 Very High Very High Very High
Apoptosis 45 88.80 High High
Cancer 127 78.08 Quite High
Stress 12 75.04 Quite High
Breast Cancer 25 71.28 Quite High
Reprotox - General 1 8 66.72 Quite High
Prostate Cancer 27 64.40 Quite High
Death 18 63.60 Quite High
Targeted Disruption 2 12.16 Low Low
Metastasis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the exception of the ventral lobe, we did not detect major differences in clusterin expression between mouse strains.
Neg (not) Regulation (differences) of Gene_expression (expression) of clusterin in ventral lobe associated with sprains and strains
1) Confidence 0.33 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.81 Pain Relevance 0
NC performed the experiments designed to demonstrate that the over-expression of clusterin did not alter the sensitivity of the transfected cells to estradiol.
Neg (not) Regulation (alter) of Gene_expression (over) of clusterin
2) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.34 Pain Relevance 0
Our previous studies have suggested that in MCF-7 cells clusterin biogenesis is altered by profound changes in the post-translational modifications that occur after treatment with tamoxifen.
Regulation (altered) of Gene_expression (biogenesis) of clusterin in MCF-7
3) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.30 Pain Relevance 0

General Comments

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