INT233561

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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 67
Disease Relevance 45.63
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Clu) extracellular space (Clu) cell death (Clu)
extracellular region (Clu) endoplasmic reticulum (Clu) nucleus (Clu)
Anatomy Link Frequency
MCF-7 16
lymph nodes 3
lungs 3
circulating cells 2
cleavage 1
Clu (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 24 99.64 Very High Very High Very High
cytokine 178 96.68 Very High Very High Very High
Inflammation 91 92.08 High High
chemokine 20 67.80 Quite High
Inflammatory mediators 5 46.80 Quite Low
Central nervous system 44 41.60 Quite Low
anesthesia 66 5.00 Very Low Very Low Very Low
imagery 54 5.00 Very Low Very Low Very Low
halothane 8 5.00 Very Low Very Low Very Low
addiction 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 2128 100.00 Very High Very High Very High
Apoptosis 1268 100.00 Very High Very High Very High
Sprains And Strains 1005 99.82 Very High Very High Very High
INFLAMMATION 119 99.46 Very High Very High Very High
Breast Cancer 656 99.18 Very High Very High Very High
Death 494 99.16 Very High Very High Very High
Infection 253 98.92 Very High Very High Very High
Reprotox - General 1 220 98.32 Very High Very High Very High
Togavirus Infection 300 98.12 Very High Very High Very High
Metastasis 125 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously shown that clusterin expression is increased in tumors developing in mice with a prostate specific deletion of the Pten tumor suppressor gene [23].
Gene_expression (expression) of clusterin associated with cancer
1) Confidence 0.66 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.75 Pain Relevance 0
We next performed immunohistochemistry to determine the cellular localization of clusterin expression.
Gene_expression (expression) of clusterin
2) Confidence 0.66 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.75 Pain Relevance 0
The expression of Psca varied up to 40-fold between strains and the expression of Clusterin was at least 70-fold greater in the FVB/N mice relative to any other strain.


Gene_expression (expression) of Clusterin associated with sprains and strains
3) Confidence 0.66 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.77 Pain Relevance 0.03
Some genes related to the inflammatory response, such as Cxcl10, Clu and antigen presentation, such as B2m, Fcer1g showed over-expression only at 72 and 96 hr post infection (Fig 2).
Gene_expression (expression) of Clu associated with inflammatory response and infection
4) Confidence 0.62 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 0.91 Pain Relevance 0.05
Clu-activated microglia showed increased MHC class II expression, secreted reactive nitrogen intermediates and TNF-?
Gene_expression (expression) of Clu in microglia
5) Confidence 0.62 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.49 Pain Relevance 0.36
A western blot analysis using ventral prostate protein extracts detected higher clusterin levels in prostates of the FVB/N strain when compared with DBA/2 and C57BL/6 strains (Figure 4b).
Gene_expression (detected) of clusterin in ventral associated with sprains and strains
6) Confidence 0.57 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.85 Pain Relevance 0
Staining was particularly intense in the apical region of the epithelium, suggesting that the secretory form of clusterin is the predominant differentially expressed isoform in FVB/N ventral prostate epithelium (Figure 4c,d).
Gene_expression (expressed) of clusterin in epithelium
7) Confidence 0.57 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.78 Pain Relevance 0
With the exception of the ventral lobe, we did not detect major differences in clusterin expression between mouse strains.
Gene_expression (expression) of clusterin in ventral lobe associated with sprains and strains
8) Confidence 0.57 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.81 Pain Relevance 0
The expression of clusterin was assessed in four independent animals per strain.


Gene_expression (expression) of clusterin associated with sprains and strains
9) Confidence 0.57 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.29 Pain Relevance 0
Although RT-PCR analysis was not quantitative, consistent with microarray analysis, gene expression of Fcer1g, Oas1b and Clu was higher at 48, 72 and 96 hr post infection as compared to saline control and 24 hr post infection (Fig 4)


Gene_expression (expression) of Clu associated with infection
10) Confidence 0.55 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.09 Pain Relevance 0
As shown in Fig 4, the expression of genes Oas1b, Fcre1g and Clu was up-regulated in mouse brain infected with VEEV.
Gene_expression (expression) of Clu in brain associated with togavirus infection
11) Confidence 0.55 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 0.95 Pain Relevance 0
Pathological or engineered over-expression of clusterin in various cell types confers resistance to the induction of apoptosis by several cytokines including TGFbeta, and TNFalpha [22-24] and promotes tumor progression in the prostate [25,26].
Gene_expression (over) of clusterin associated with cancer, apoptosis and cytokine
12) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.88 Pain Relevance 0.05
The observation that clusterin over-expression also stimulates invasion and metastatic progression, at least to the lungs, suggests that the secreted glycoprotein has additional extracellular functions.
Gene_expression (expression) of clusterin in lungs
13) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.34 Pain Relevance 0
Over-expression of clusterin or other secretory proteins does not appear to induce an ER-overload response [38], and it is unlikely that the glycosylation, processing or trafficking of the glycoprotein is altered as a consequence of over-expression.
Gene_expression (expression) of clusterin
14) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.23 Pain Relevance 0
Thus, while the protein is clearly expressed in cells that are destined to undergo apoptosis, the observation that high levels of clusterin expression is also seen in surviving cells suggests that it may play a role in cell survival.
Gene_expression (expression) of clusterin associated with apoptosis
15) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 1.05 Pain Relevance 0.05
While the synthesis of clusterin and the appearance of the nuclear isoform is clearly upregulated during apoptosis, the role of the secretory protein in either cell death or cell survival has not been clearly delineated.
Gene_expression (synthesis) of clusterin associated with apoptosis and death
16) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.77 Pain Relevance 0
This alteration was generated to allow for expression of a C-terminal GFP-tagged clusterin (pEXP-CLUGFP).
Gene_expression (expression) of clusterin
17) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.09 Pain Relevance 0
Over-expression of this clusterin isoform, which binds to Ku70/80 has been shown to induce apoptosis in MCF-7 cells [13].
Gene_expression (Over) of clusterin isoform in MCF-7 associated with apoptosis
18) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.27 Pain Relevance 0
We chose to evaluate protein levels of clusterin, which is encoded by a gene studied extensively in the context of prostate carcinogenesis and therapy resistance [20-22].
Gene_expression (levels) of clusterin
19) Confidence 0.51 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.66 Pain Relevance 0
It is likely that chronic over-expression of clusterin in cells which survive therapy results in the clustering of tumor cells, platelets and other circulating cells to form emboli, possibly as a by-product of the function of the glycoprotein as an extracellular chaperone, as originally described by Fritz and his colleagues who first described and named the protein [46].
Gene_expression (over) of clusterin in circulating cells associated with cancer
20) Confidence 0.46 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.72 Pain Relevance 0

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