INT233567

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.91
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Clu) extracellular space (Clu) cell death (Clu)
extracellular region (Clu) endoplasmic reticulum (Clu) nucleus (Clu)
Anatomy Link Frequency
MCF-7 2
Clu (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 18 98.24 Very High Very High Very High
cytokine 13 25.00 Low Low
Central nervous system 11 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 37 99.48 Very High Very High Very High
Infection 53 99.12 Very High Very High Very High
Apoptosis 83 98.46 Very High Very High Very High
Stress 16 98.28 Very High Very High Very High
INFLAMMATION 23 98.24 Very High Very High Very High
Prostate Cancer 27 98.12 Very High Very High Very High
Disease 15 91.76 High High
Sprains And Strains 126 89.20 High High
Death 29 88.32 High High
Togavirus Infection 75 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on these results, we speculate that elevated clusterin levels may contribute to the enhanced rate of prostate tumor development and progression observed in the TRAMP FVB/N genotype.


Positive_regulation (elevated) of clusterin associated with prostate cancer
1) Confidence 0.59 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.97 Pain Relevance 0
The intracellular levels of clusterin in the MCF-7 CLU cell line is increased between 10-15 fold by 48 h compared to the parental line (Figure 1 panels B and C).
Positive_regulation (increased) of clusterin in MCF-7
2) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.11 Pain Relevance 0
Our results demonstrate that genes related to important immune pathways such as antigen presentation, inflammation, apoptosis and response to virus (Cxcl10, CxCl11, Ccl5, Ifr7, Ifi27 Oas1b, Fcerg1,Mif, Clusterin and MHC class II) were upregulated as a result of virus infection.
Positive_regulation (upregulated) of Clusterin associated with inflammation, apoptosis and infection
3) Confidence 0.43 Published 2008 Journal BMC Genomics Section Abstract Doc Link PMC2440554 Disease Relevance 1.14 Pain Relevance 0.09
Clusterin is a secreted glycoprotein that is upregulated in a variety of cell lines in response to stress, and enhances cell survival.
Positive_regulation (upregulated) of Clusterin associated with stress
4) Confidence 0.28 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2856549 Disease Relevance 0.63 Pain Relevance 0
This is reflected by a substantial increase in the levels of extracellular clusterin (Figure 1 panel B), however since it is not possible to normalize the levels of extracellular clusterin, it is only possible to state that the transfected cell line secretes approximately 10-15 times more clusterin than the untransfected, unstressed MCF-7 cells.
Positive_regulation (increase) of clusterin in MCF-7
5) Confidence 0.28 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.05 Pain Relevance 0

General Comments

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