INT2336

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Context Info
Confidence 0.58
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 51
Total Number 53
Disease Relevance 33.79
Pain Relevance 13.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Lct) carbohydrate metabolic process (Lct)
Anatomy Link Frequency
bowel 8
ileum 1
jejunum 1
pancreas 1
duodenum 1
Lct (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 1 100.00 Very High Very High Very High
spastic colon 51 99.96 Very High Very High Very High
Fibrositis 7 99.82 Very High Very High Very High
cINOD 10 99.74 Very High Very High Very High
Morphine 6 99.58 Very High Very High Very High
abdominal pain 63 99.36 Very High Very High Very High
tolerance 16 99.32 Very High Very High Very High
Crohn's disease 10 99.28 Very High Very High Very High
Inflammation 10 99.08 Very High Very High Very High
Pain 30 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Malabsorption Syndromes 133 100.00 Very High Very High Very High
Functional Bowel Disorder 39 99.96 Very High Very High Very High
Thyroid Disease 3 99.96 Very High Very High Very High
Diarrhoea 26 99.92 Very High Very High Very High
Colon Cancer 1 99.92 Very High Very High Very High
Lactose Intolerance 40 99.90 Very High Very High Very High
Fibromyalgia 5 99.82 Very High Very High Very High
Disease 16 99.66 Very High Very High Very High
Syndrome 2 99.66 Very High Very High Very High
Celiac Disease 3 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lactase deficiency was found in 5 of the 80 subjects with the irritable bowel syndrome and in 6 of the 100 subjects without intestinal symptoms who were of comparable ethnic background.
Negative_regulation (deficiency) of Lactase in bowel associated with spastic colon and malabsorption syndromes
1) Confidence 0.58 Published 1983 Journal Mayo Clin. Proc. Section Abstract Doc Link 6843184 Disease Relevance 0.94 Pain Relevance 0.43
Eighty subjects with the irritable bowel syndrome who were white, non-Jewish, and of northern-western European background were screened for lactase deficiency by means of the hydrogen breath test.
Negative_regulation (deficiency) of lactase in bowel associated with spastic colon and malabsorption syndromes
2) Confidence 0.58 Published 1983 Journal Mayo Clin. Proc. Section Abstract Doc Link 6843184 Disease Relevance 0.93 Pain Relevance 0.43
CONCLUSIONS: The prevalence of lactase deficiency among this group of Malaysian children with recurrent abdominal pain was high, but lactase deficiency did not appear to play an important role in causing the symptoms.


Negative_regulation (deficiency) of lactase
3) Confidence 0.58 Published 2001 Journal J Paediatr Child Health Section Body Doc Link 11328471 Disease Relevance 0 Pain Relevance 0
Lactose malabsorption is characterized by a deficiency of mucosal lactase.
Negative_regulation (deficiency) of lactase associated with lactose intolerance
4) Confidence 0.57 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9824144 Disease Relevance 0.99 Pain Relevance 0.36
However, 16 of 61 (26.4%) control subjects matched for age and ethnic background exhibited lactase deficiency.
Negative_regulation (deficiency) of lactase associated with malabsorption syndromes
5) Confidence 0.57 Published 1981 Journal Pediatrics Section Abstract Doc Link 7195004 Disease Relevance 0.89 Pain Relevance 0.70
Thus, a similar prevalence of lactase deficiency was found in the control and the recurrent abdominal pain groups.
Negative_regulation (deficiency) of lactase associated with abdominal pain and malabsorption syndromes
6) Confidence 0.57 Published 1981 Journal Pediatrics Section Abstract Doc Link 7195004 Disease Relevance 0.91 Pain Relevance 0.72
All infected children were symptomatic, malabsorption could be demonstrated in 5/8, lactase levels were reduced in most children.
Negative_regulation (reduced) of lactase
7) Confidence 0.57 Published 1978 Journal Padiatr Padol Section Abstract Doc Link 643294 Disease Relevance 0.83 Pain Relevance 0.07
Lactase deficiency: not more common in pediatric patients with inflammatory bowel disease than in patients with chronic abdominal pain.
Negative_regulation (deficiency) of Lactase in bowel associated with abdominal pain, inflammation and malabsorption syndromes
8) Confidence 0.57 Published 2002 Journal J. Pediatr. Gastroenterol. Nutr. Section Title Doc Link 12352524 Disease Relevance 0.29 Pain Relevance 0.19
The prevalence of lactase deficiency in patients with IBD was 37% (38 of 103) in white patients and 78% (7 of 9) in blacks.
Negative_regulation (deficiency) of lactase
9) Confidence 0.57 Published 2002 Journal J. Pediatr. Gastroenterol. Nutr. Section Body Doc Link 12352524 Disease Relevance 0.28 Pain Relevance 0
Both adaptation to continued use of milk and milk products and relationships of milk use to various disease states in which intestinal lactase activity may be reduced are discussed.
Negative_regulation (reduced) of intestinal lactase associated with disease
10) Confidence 0.50 Published 1988 Journal Arch Latinoam Nutr Section Abstract Doc Link 3155250 Disease Relevance 0.21 Pain Relevance 0.09
On the basis of a review of over 560 references, all available data on the primary loss of intestinal lactase in Latin American populations are presented in tabular form.
Negative_regulation (loss) of intestinal lactase
11) Confidence 0.50 Published 1988 Journal Arch Latinoam Nutr Section Abstract Doc Link 3155250 Disease Relevance 0.18 Pain Relevance 0.13
Excellent agreement between genetic and hydrogen breath tests for lactase deficiency and the role of extended symptom assessment.
Negative_regulation (deficiency) of lactase associated with malabsorption syndromes
12) Confidence 0.43 Published 2010 Journal Br. J. Nutr. Section Title Doc Link 20398434 Disease Relevance 0.10 Pain Relevance 0
Clinical manifestations of lactase (LCT) deficiency include intestinal and extra-intestinal symptoms.
Negative_regulation (deficiency) of lactase
13) Confidence 0.43 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 20398434 Disease Relevance 0.07 Pain Relevance 0
Clinical manifestations of lactase (LCT) deficiency include intestinal and extra-intestinal symptoms.
Negative_regulation (deficiency) of LCT
14) Confidence 0.43 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 20398434 Disease Relevance 0.07 Pain Relevance 0
A sizable number of adults believe they are lactose intolerant but do not actually have impaired lactose digestion, and some persons with lactase deficiency can tolerate moderate amounts of ingested lactose.
Negative_regulation (deficiency) of lactase associated with malabsorption syndromes
15) Confidence 0.43 Published 2002 Journal Am Fam Physician Section Abstract Doc Link 12018807 Disease Relevance 0.82 Pain Relevance 0.16
After exclusion of milk from the diet, three of the five subjects with lactase deficiency and the irritable bowel syndrome had partial to complete relief of symptoms for 3 weeks, and two of these had sustained relief for 1 year (one with complete and one with 75% improvement).
Negative_regulation (deficiency) of lactase in bowel associated with spastic colon and malabsorption syndromes
16) Confidence 0.43 Published 1983 Journal Mayo Clin. Proc. Section Abstract Doc Link 6843184 Disease Relevance 0.95 Pain Relevance 0.43
Role of lactase deficiency.
Negative_regulation (deficiency) of lactase associated with malabsorption syndromes
17) Confidence 0.43 Published 1983 Journal Mayo Clin. Proc. Section Title Doc Link 6843184 Disease Relevance 0.96 Pain Relevance 0.45
Lactase deficiency was found to be a relatively uncommon cause of irritable bowel symptoms among non-Jewish whites who are of northern-western European background.
Negative_regulation (deficiency) of Lactase in bowel associated with malabsorption syndromes
18) Confidence 0.43 Published 1983 Journal Mayo Clin. Proc. Section Abstract Doc Link 6843184 Disease Relevance 0.90 Pain Relevance 0.40
Lactase deficiency is present in up to 15 percent of persons of northern European descent, up to 80 percent of blacks and Latinos, and up to 100 percent of American Indians and Asians.
Negative_regulation (deficiency) of Lactase associated with malabsorption syndromes
19) Confidence 0.43 Published 2002 Journal Am Fam Physician Section Abstract Doc Link 12018807 Disease Relevance 0.70 Pain Relevance 0.17
In adults with the irritable bowel syndrome who had no history of milk intolerance, the prevalence of lactase deficiency and the value of lactose restriction were determined.
Negative_regulation (deficiency) of lactase in bowel associated with spastic colon and malabsorption syndromes
20) Confidence 0.43 Published 1983 Journal Mayo Clin. Proc. Section Abstract Doc Link 6843184 Disease Relevance 0.80 Pain Relevance 0.40

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