INT233605

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.05
Pain Relevance 3.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tsc22d3) cytoplasm (Tsc22d3)
Anatomy Link Frequency
finger 4
Tsc22d3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 706 99.98 Very High Very High Very High
Opioid 119 84.96 Quite High
tolerance 32 84.08 Quite High
withdrawal 36 76.60 Quite High
adenocard 8 75.24 Quite High
Physical dependence 40 71.32 Quite High
antagonist 32 68.88 Quite High
Nucleus accumbens 18 55.52 Quite High
Glutamate receptor 5 47.28 Quite Low
Neuropeptide 4 45.60 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 328 99.72 Very High Very High Very High
Adhesions 4 81.80 Quite High
Skin Cancer 4 81.24 Quite High
Opiate Addiction 32 76.60 Quite High
Nervous System Malformation 16 72.28 Quite High
Drug Dependence 51 71.32 Quite High
Shock 34 59.12 Quite High
Apoptosis 33 34.84 Quite Low
Stress 20 27.92 Quite Low
Respiratory Failure 4 25.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The qPCR method was used to evaluate the influence of GR blockade on acute morphine-induced gene transcription of selected genes (Tsc22d3, Nfkbia, Zbtb16, Sgk, and Fzd2).
Positive_regulation (induced) of Transcription (transcription) of Tsc22d3 associated with morphine
1) Confidence 0.69 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.30 Pain Relevance 0.90
However, transcription of Sgk1 and Tsc22d3 was not activated during the behavioral expression of morphine-induced CPP (Figure 3b).
Neg (not) Positive_regulation (activated) of Transcription (transcription) of Tsc22d3 associated with morphine
2) Confidence 0.68 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.38
However, mRNA level of Tsc22d3 was also noticeably elevated in the three other strains (Figure 4c).


Positive_regulation (elevated) of Transcription (level) of Tsc22d3 associated with sprains and strains
3) Confidence 0.50 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.64 Pain Relevance 0.43
Increased mRNA abundance of TSC22 domain family 3 (Tsc22d3) and zinc finger and BTB domain containing 16 (Zbtb16) transcripts was found to be positively related to morphine preference (Figure 7).
Positive_regulation (Increased) of Transcription (abundance) of TSC22 domain family 3 in finger associated with morphine
4) Confidence 0.50 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.55 Pain Relevance 1.13
Increased mRNA abundance of TSC22 domain family 3 (Tsc22d3) and zinc finger and BTB domain containing 16 (Zbtb16) transcripts was found to be positively related to morphine preference (Figure 7).
Positive_regulation (Increased) of Transcription (abundance) of Tsc22d3 in finger associated with morphine
5) Confidence 0.50 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.55 Pain Relevance 1.14

General Comments

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