INT233606

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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.55
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
locus coeruleus 1
Nfkbia (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 688 99.72 Very High Very High Very High
withdrawal 36 98.78 Very High Very High Very High
Locus ceruleus 4 98.36 Very High Very High Very High
Hippocampus 12 90.84 High High
alcohol 4 80.16 Quite High
antagonist 24 70.32 Quite High
drug abuse 4 68.00 Quite High
Glutamate receptor 4 67.52 Quite High
Neuropeptide 4 65.84 Quite High
Nucleus accumbens 16 63.44 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 328 99.96 Very High Very High Very High
Adhesions 4 81.28 Quite High
Skin Cancer 4 80.72 Quite High
Shock 32 79.36 Quite High
Nervous System Malformation 16 71.76 Quite High
Stress 12 69.32 Quite High
Drug Dependence 48 68.00 Quite High
Opiate Addiction 32 54.20 Quite High
Apoptosis 32 34.32 Quite Low
Decapitation 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The qPCR method was used to evaluate the influence of GR blockade on acute morphine-induced gene transcription of selected genes (Tsc22d3, Nfkbia, Zbtb16, Sgk, and Fzd2).
Transcription (transcription) of Nfkbia associated with morphine
1) Confidence 0.66 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.30 Pain Relevance 0.90
Uniquely in the C57BL/6J strain, abundance of Nfkbia mRNA was increased almost twofold after acute morphine compared with control.
Transcription (abundance) of Nfkbia associated with sprains and strains and morphine
2) Confidence 0.57 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.71 Pain Relevance 0.42
It is well established that gene transcription of Nfkbia as well as Tsc22d3 can be mediated by GR and controlled by the level of glucocorticoids [17,31].
Transcription (transcription) of Nfkbia
3) Confidence 0.57 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.33 Pain Relevance 0.64
Withdrawal from chronic morphine treatment induced changes in the mRNA abundance of Sgk and Nfkbia in rat prefrontal cortex [42] and mouse locus coeruleus [22].
Transcription (abundance) of Nfkbia in locus coeruleus associated with locus ceruleus, withdrawal and morphine
4) Confidence 0.55 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.21 Pain Relevance 0.75

General Comments

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