INT233612

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.55
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
locus coeruleus 2
Nfkbia (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 344 99.62 Very High Very High Very High
withdrawal 18 99.18 Very High Very High Very High
Locus ceruleus 2 98.36 Very High Very High Very High
Hippocampus 6 91.64 High High
alcohol 2 80.96 Quite High
antagonist 12 70.32 Quite High
drug abuse 2 68.00 Quite High
Nucleus accumbens 8 64.24 Quite High
Opioid 56 62.56 Quite High
tolerance 16 61.68 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 164 85.68 High High
Stress 6 70.12 Quite High
Drug Dependence 24 68.00 Quite High
Opiate Addiction 16 54.20 Quite High
Apoptosis 16 5.00 Very Low Very Low Very Low
Shock 16 5.00 Very Low Very Low Very Low
Nervous System Malformation 8 5.00 Very Low Very Low Very Low
Decapitation 4 5.00 Very Low Very Low Very Low
Hypothermia 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is well established that gene transcription of Nfkbia as well as Tsc22d3 can be mediated by GR and controlled by the level of glucocorticoids [17,31].
Regulation (controlled) of Transcription (transcription) of Nfkbia
1) Confidence 0.36 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.33 Pain Relevance 0.65
Withdrawal from chronic morphine treatment induced changes in the mRNA abundance of Sgk and Nfkbia in rat prefrontal cortex [42] and mouse locus coeruleus [22].
Regulation (changes) of Transcription (abundance) of Nfkbia in locus coeruleus associated with locus ceruleus, withdrawal and morphine
2) Confidence 0.36 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.22 Pain Relevance 0.78

General Comments

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