INT233635

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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.02
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Zbtb16) plasma membrane (Zbtb16) nucleus (Zbtb16)
DNA binding (Zbtb16)
Anatomy Link Frequency
finger 1
Zbtb16 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 516 99.72 Very High Very High Very High
Opioid 84 80.72 Quite High
tolerance 24 79.84 Quite High
withdrawal 27 72.36 Quite High
adenocard 6 71.00 Quite High
antagonist 18 70.16 Quite High
Physical dependence 30 67.08 Quite High
opiate 12 29.52 Quite Low
depression 3 20.84 Low Low
addiction 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 24 98.30 Very High Very High Very High
Sprains And Strains 246 95.48 Very High Very High Very High
Nervous System Malformation 12 93.84 High High
Adhesions 3 81.28 Quite High
Skin Cancer 3 80.72 Quite High
Opiate Addiction 24 72.36 Quite High
Drug Dependence 36 67.08 Quite High
Respiratory Failure 3 20.84 Low Low
Hypoxia 3 19.52 Low Low
Shock 24 16.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The qPCR method was used to evaluate the influence of GR blockade on acute morphine-induced gene transcription of selected genes (Tsc22d3, Nfkbia, Zbtb16, Sgk, and Fzd2).
Transcription (transcription) of Zbtb16 associated with morphine
1) Confidence 0.66 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.30 Pain Relevance 0.91
Increased mRNA abundance of TSC22 domain family 3 (Tsc22d3) and zinc finger and BTB domain containing 16 (Zbtb16) transcripts was found to be positively related to morphine preference (Figure 7).
Transcription (transcripts) of Zbtb16 in finger associated with morphine
2) Confidence 0.64 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.53 Pain Relevance 0.99
Also, genes associated with negative regulation of cellular processes (GO: 0048532; 17 transcripts; P = 0.001) and regulation of apoptosis (GO: 0042981; ten transcripts; P = 0.005) were over-represented, including Sgk3 and Zbtb16 transcripts.
Transcription (transcripts) of Zbtb16 associated with apoptosis
3) Confidence 0.64 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.19 Pain Relevance 0.48

General Comments

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