INT233640

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.02
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Olig2) nucleus (Olig2) DNA binding (Olig2)
cytoplasm (Olig2)
Anatomy Link Frequency
oligodendrocyte 3
neuron 2
white matter 1
Olig2 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 688 100.00 Very High Very High Very High
cocaine 6 97.20 Very High Very High Very High
Central nervous system 86 93.16 High High
Inflammation 28 93.00 High High
imagery 10 68.36 Quite High
Hippocampus 50 64.64 Quite High
withdrawal 36 61.36 Quite High
Opioid 112 60.92 Quite High
Physical dependence 40 5.00 Very Low Very Low Very Low
tolerance 34 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 4 99.56 Very High Very High Very High
Death 20 95.16 Very High Very High Very High
Apoptosis 56 93.72 High High
Schizophrenia 4 93.08 High High
INFLAMMATION 28 93.00 High High
Neurodegenerative Disease 2 89.08 High High
Cognitive Disorder 14 72.48 Quite High
Leukoencephalopathies 8 69.92 Quite High
Pressure And Volume Under Development 4 68.64 Quite High
Opiate Addiction 32 61.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with the majority of the cell bodies in the mature CC belonging to oligodendrocytes or glial progenitor cells, the decrease in the number of CC1+ cells at 6 months matched the decrease of Olig2 labeling (data not shown), confirming loss of oligodendrocytes at this time point.

5-FU treatment causes only transient brain vasculature endothelial cell apoptosis and CNS inflammation in a subset of treated animals

Negative_regulation (decrease) of Olig2 in oligodendrocytes associated with inflammation, central nervous system and apoptosis
1) Confidence 0.54 Published 2008 Journal J Biol Section Body Doc Link PMC2397490 Disease Relevance 0.39 Pain Relevance 0.20
Moreover, one of the genes with decreased mRNA level after repeated morphine treatment, namely oligodendrocyte transcription factor 2 (Olig2), was identified as an essential transcriptional regulator in neuron and oligodendrocyte specification [25] and was recently postulated to be involved in susceptibility to schizophrenia [26].
Negative_regulation (decreased) of oligodendrocyte transcription factor 2 in oligodendrocyte associated with schizophrenia and morphine
2) Confidence 0.42 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.21 Pain Relevance 0.77
Moreover, one of the genes with decreased mRNA level after repeated morphine treatment, namely oligodendrocyte transcription factor 2 (Olig2), was identified as an essential transcriptional regulator in neuron and oligodendrocyte specification [25] and was recently postulated to be involved in susceptibility to schizophrenia [26].
Negative_regulation (decreased) of Olig2 in oligodendrocyte associated with schizophrenia and morphine
3) Confidence 0.42 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.21 Pain Relevance 0.77
Recent findings that aging is associated with a loss of expression of important transcriptional regulators, including Olig2, in oligodendrocytes [176] and may be associated with degenerative white matter changes [177-185] also raises the possibility, however, that the effect of 5-FU results from an acceleration of the normal aging processes.
Negative_regulation (loss) of Olig2 in white matter associated with aging
4) Confidence 0.39 Published 2008 Journal J Biol Section Body Doc Link PMC2397490 Disease Relevance 0.79 Pain Relevance 0.18
Moreover, one of the genes with decreased mRNA level after repeated morphine treatment, namely oligodendrocyte transcription factor 2 (Olig2), was identified as an essential transcriptional regulator in neuron and oligodendrocyte specification [25] and was recently postulated to be involved in susceptibility to schizophrenia [26].
Negative_regulation (decreased) of oligodendrocyte transcription factor 2 in neuron associated with schizophrenia and morphine
5) Confidence 0.14 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.21 Pain Relevance 0.77
Moreover, one of the genes with decreased mRNA level after repeated morphine treatment, namely oligodendrocyte transcription factor 2 (Olig2), was identified as an essential transcriptional regulator in neuron and oligodendrocyte specification [25] and was recently postulated to be involved in susceptibility to schizophrenia [26].
Negative_regulation (decreased) of Olig2 in neuron associated with schizophrenia and morphine
6) Confidence 0.14 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.21 Pain Relevance 0.77

General Comments

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