INT233650

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Context Info
Confidence 0.64
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.56
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Zbtb16) plasma membrane (Zbtb16) nucleus (Zbtb16)
DNA binding (Zbtb16)
Anatomy Link Frequency
finger 2
lung 1
Zbtb16 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 344 99.80 Very High Very High Very High
antagonist 12 97.44 Very High Very High Very High
Eae 14 76.08 Quite High
Inflammation 33 64.96 Quite High
cytokine 8 63.92 Quite High
chemokine 6 62.40 Quite High
Opioid 56 49.52 Quite Low
Analgesic 6 34.88 Quite Low
tolerance 16 34.08 Quite Low
Physical dependence 20 21.44 Low Low
Disease Link Frequency Relevance Heat
Body Weight 30 100.00 Very High Very High Very High
Sprains And Strains 218 98.76 Very High Very High Very High
Shock 17 98.58 Very High Very High Very High
Death 4 97.24 Very High Very High Very High
Stress 7 96.68 Very High Very High Very High
Cancer 17 84.28 Quite High
Myocarditis 24 81.04 Quite High
Reticuloendotheliosis 1 80.24 Quite High
Aids-related Complex 71 79.76 Quite High
Acute-phase Reaction 2 74.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prior administration of RU486 blocked morphine-produced induction of Tsc22d3, Zbtb16, and Nfkbia mRNAs.
Positive_regulation (induction) of Zbtb16 associated with morphine
1) Confidence 0.64 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.05 Pain Relevance 0.64
Genes both up and downstream from TP53 and MYC were those with functional roles in cellular stress responses and/or cell death and included DnaJ homolog subfamily B member 1(DNAJB1), heat shock protein 105 kDa (HSPH1) and zinc finger and BTB domain containing 16 (ZBTB16) which was also upregulated at 4 weeks (2.4 fold).
Positive_regulation (upregulated) of ZBTB16 in finger associated with stress, shock and death
2) Confidence 0.47 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.12 Pain Relevance 0.10
Greater than twofold induction of zinc finger and BTB domain containing 16 (Zbtb16/Zfp145) mRNA after acute treatment was confirmed, and this induction was lower after prolonged administration.
Positive_regulation (induction) of Zbtb16 in finger
3) Confidence 0.47 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.28 Pain Relevance 0.55
The lung weight (LuW)/BW ratio on days 4 and 6 was increased in groups A and B compared with group N.
Positive_regulation (increased) of LuW in lung associated with body weight
4) Confidence 0.00 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2887330 Disease Relevance 1.10 Pain Relevance 0

General Comments

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