INT23366

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Context Info
Confidence 0.50
First Reported 1983
Last Reported 2005
Negated 3
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.11
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Tshb) cellular_component (Tshb)
Anatomy Link Frequency
thyroid 5
head 1
body 1
Tshb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 16 99.52 Very High Very High Very High
Migraine 4 96.56 Very High Very High Very High
Opioid 2 91.28 High High
tolerance 2 91.16 High High
opiate 7 75.00 Quite High
iatrogenic 2 72.56 Quite High
depression 59 72.16 Quite High
anesthesia 3 71.24 Quite High
Enkephalin 1 68.56 Quite High
spastic colon 12 60.60 Quite High
Disease Link Frequency Relevance Heat
Hypothyroidism 90 99.50 Very High Very High Very High
Hyperplasia 6 96.68 Very High Very High Very High
Migraine Without Aura 2 96.56 Very High Very High Very High
Hypertrophy 8 94.80 High High
Impaired Glucose Tolerance 2 91.16 High High
Headache 2 88.88 High High
Obesity 5 86.68 High High
Intellectual Impairment 2 85.28 High High
Body Weight 9 82.96 Quite High
Congenital Anomalies 4 81.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRH treatment increased TSH beta mRNA on 12 and 24 h after the treatment on day 2 and 3 but did not increase TSH beta mRNA on day 6.
Neg (not) Positive_regulation (increase) of TSH beta mRNA
1) Confidence 0.50 Published 1994 Journal J. Neuroendocrinol. Section Abstract Doc Link 7827627 Disease Relevance 0.07 Pain Relevance 0.07
TRH treatment increased TSH beta mRNA on 12 and 24 h after the treatment on day 2 and 3 but did not increase TSH beta mRNA on day 6.
Neg (not) Positive_regulation (increased) of TSH beta mRNA
2) Confidence 0.50 Published 1994 Journal J. Neuroendocrinol. Section Abstract Doc Link 7827627 Disease Relevance 0.07 Pain Relevance 0.07
Following direct administration of thyrotropin-releasing hormone (TRH), but not thyroid-stimulating hormone (TSH) or vehicle solution, into the lateral cerebral ventricle in rats, three main categories of behaviour were provoked: activity of the normal type--stimulation of forward locomotion, head and body rearing (as shown by an enhancement in gross movements); stereotyped activity--increased grooming and head swaying (as shown by an enhancement in fine movements); abnormal behaviour--tail elevation and piloerection (as observed grossly).
Positive_regulation (administration) of thyroid-stimulating hormone in head
3) Confidence 0.28 Published 1983 Journal Neuropharmacology Section Abstract Doc Link 6304565 Disease Relevance 0 Pain Relevance 0.16
Overt hypothyroidism refers to patients with elevated thyroid stimulating hormone (TSH) levels and low free thyroxine (T4) levels.
Positive_regulation (elevated) of thyroid stimulating hormone in thyroid associated with hypothyroidism
4) Confidence 0.25 Published 2005 Journal Chiropr Osteopat Section Body Doc Link PMC1151653 Disease Relevance 1.18 Pain Relevance 0.04
In PB-and PTU-treated rats, thyroid-stimulating hormone (TSH) levels were significantly elevated, and both thyroxine and triiodothyronine hormone levels were significantly decreased.
Positive_regulation (elevated) of thyroid-stimulating hormone in thyroid
5) Confidence 0.22 Published 2005 Journal Environ Health Perspect Section Abstract Doc Link PMC1281279 Disease Relevance 0.58 Pain Relevance 0
Primary hypothyroidism is characterised by reduced free thyroxine (FT4) levels and elevated thyroid stimulating hormone (TSH) levels.
Positive_regulation (elevated) of thyroid stimulating hormone in thyroid associated with hypothyroidism
6) Confidence 0.17 Published 2005 Journal Chiropr Osteopat Section Body Doc Link PMC1151653 Disease Relevance 0.83 Pain Relevance 0.17
Naloxone (NAL) 10(-5) M was found to increase basal TSH, alpha subunit and TSH-beta secretion.
Positive_regulation (increase) of TSH-beta associated with narcan
7) Confidence 0.10 Published 1985 Journal Acta Endocrinol. Section Abstract Doc Link 2412379 Disease Relevance 0 Pain Relevance 0.55
Following direct administration of thyrotropin-releasing hormone (TRH), but not thyroid-stimulating hormone (TSH) or vehicle solution, into the lateral cerebral ventricle in rats, three main categories of behaviour were provoked: activity of the normal type--stimulation of forward locomotion, head and body rearing (as shown by an enhancement in gross movements); stereotyped activity--increased grooming and head swaying (as shown by an enhancement in fine movements); abnormal behaviour--tail elevation and piloerection (as observed grossly).
Positive_regulation (administration) of thyroid-stimulating hormone in body
8) Confidence 0.10 Published 1983 Journal Neuropharmacology Section Abstract Doc Link 6304565 Disease Relevance 0 Pain Relevance 0.16
The thyroid-stimulating hormone (TSH) response was enhanced after 50 micrograms TRH in the migraineurs, but not after 200 micrograms.
Neg (not) Positive_regulation (enhanced) of thyroid-stimulating hormone in thyroid
9) Confidence 0.03 Published 1987 Journal Cephalalgia Section Abstract Doc Link 3123067 Disease Relevance 0.26 Pain Relevance 0.37
Compared to controls, AP-treated women displayed significantly higher levels of basal glucose, insulin after 60 min of the glucose overload, prolactin, thyroid stimulating hormone and beta-endorphin, with lower levels of C-Peptide, progesterone, 17-OH progesterone, androstenedione and high-density lipoprotein cholesterol.
Positive_regulation (after) of thyroid stimulating hormone in thyroid
10) Confidence 0.01 Published 2001 Journal Pharmacopsychiatry Section Abstract Doc Link 11778142 Disease Relevance 1.07 Pain Relevance 0.21

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