INT23367

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Context Info
Confidence 0.50
First Reported 1983
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 0.97
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
blood 2
neurons 2
pituitary gland 2
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 25 100.00 Very High Very High Very High
cytokine 5 100.00 Very High Very High Very High
antagonist 7 99.80 Very High Very High Very High
Morphine 4 99.50 Very High Very High Very High
Clonidine 2 99.50 Very High Very High Very High
anesthesia 3 99.22 Very High Very High Very High
Opioid 4 99.20 Very High Very High Very High
excitatory amino acid 1 96.92 Very High Very High Very High
Enkephalin 1 95.44 Very High Very High Very High
opiate 9 91.36 High High
Disease Link Frequency Relevance Heat
Growth Problems 1 92.40 High High
Rheumatic Heart Disease 13 84.68 Quite High
Mitral Valve Stenosis 1 70.00 Quite High
Aortic Valve Insufficiency 1 68.80 Quite High
Mitral Valve Insufficiency 1 66.80 Quite High
Urological Neuroanatomy 12 56.12 Quite High
Precocious Puberty 86 50.00 Quite Low
Myocardial Infarction 1 25.00 Low Low
Disease 4 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
l, using 200 IU M-MLV reverse transcriptase in the presence of 25 pmol GnRH specific downstream primer (Sangon Inc), 0.5 mM deoxy-NTP and 20IU Rnasin (from Promega) for 60 min at 42°C, then heat denatured for 5 min at 95°C. 5 ?
Positive_regulation (using) of Positive_regulation (presence) of GnRH
1) Confidence 0.50 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236957 Disease Relevance 0 Pain Relevance 0
Densitometric analysis of the mRNA concentration using GnRH/?
Positive_regulation (concentration) of Positive_regulation (using) of GnRH
2) Confidence 0.50 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236957 Disease Relevance 0.06 Pain Relevance 0
Possible explanations for this dichotomy in LH response include: (1) LHRH neurons in unanesthetized, estrogen-treated ovariectomized (OVX) rats are relatively unresponsive to NE, (2) the chloral hydrate anesthesia used in our brain stimulation studies elevates the threshold of excitability of LHRH neurons to norepinephrine (NE) and/or pituitary responsiveness to LHRH, (3) preliminary MPN-ECS reduces thresholds of responsiveness of LHRH neurons to NE, and (4) the LHRH secreted after MPN-ECS sensitizes the pituitary gland to the subsequent small amounts of LHRH released following LC- or A1-stimulation.
Positive_regulation (elevates) of Positive_regulation (excitability) of LHRH in pituitary gland associated with anesthesia and locus ceruleus
3) Confidence 0.47 Published 1989 Journal Brain Res. Section Abstract Doc Link 2644003 Disease Relevance 0 Pain Relevance 0.30
A complete understanding of the neuroendocrine control of ovulation will only be achieved in the future by comparative studies of several animal model systems in which mating-induced as well as spontaneous, hormonally stimulated activation of GnRH neurons drives the preovulatory LH surge.
Positive_regulation (stimulated) of Positive_regulation (activation) of GnRH in neurons
4) Confidence 0.45 Published 2000 Journal Front Neuroendocrinol Section Abstract Doc Link 10882541 Disease Relevance 0 Pain Relevance 0.15
In contrast, cytokine-induced changes in LH and GnRH secretion are mediated through pathways lying primarily beyond the blood-brain barrier.
Positive_regulation (mediated) of Positive_regulation (cytokine-induced) of GnRH in blood associated with cytokine
5) Confidence 0.45 Published 1993 Journal Ciba Found. Symp. Section Abstract Doc Link 8491087 Disease Relevance 0 Pain Relevance 0.21
Characterization and possible opioid modulation of N-methyl-D-aspartic acid induced increases in serum luteinizing hormone levels in the developing male rat.
Positive_regulation (induced) of Positive_regulation (increases) of serum luteinizing hormone associated with narcan and opioid
6) Confidence 0.45 Published 1988 Journal Life Sci. Section Title Doc Link 3283488 Disease Relevance 0 Pain Relevance 0.36
We have shown previously that acute morphine administration markedly enhances naloxone-induced increases in serum luteinizing hormone (LH) levels in the male rat.
Positive_regulation (enhances) of Positive_regulation (increases) of serum luteinizing hormone associated with narcan and morphine
7) Confidence 0.18 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6310081 Disease Relevance 0 Pain Relevance 0.85
Administration of the narcotic antagonist naloxone results in an elevation of serum luteinizing hormone (LH) levels in 10-day-old female, but not male, rats.
Positive_regulation (results) of Positive_regulation (elevation) of serum luteinizing hormone associated with antagonist and narcan
8) Confidence 0.10 Published 1988 Journal Biol. Reprod. Section Abstract Doc Link 3219373 Disease Relevance 0 Pain Relevance 0.29
Growth hormone (GH) response to clonidine provocation, LH and FSH response to LHRH stimulation, and in boys testosterone (T) response to HCG were evaluated.
Positive_regulation (response) of Positive_regulation (stimulation) of LHRH associated with clonidine
9) Confidence 0.06 Published 1997 Journal J. Trop. Pediatr. Section Abstract Doc Link 9078821 Disease Relevance 0.91 Pain Relevance 0.15
Thyrotrophin releasing hormone (TRH) stimulation of secretion of TSH and its subunits was not further augmented by NAL.
Neg (not) Positive_regulation (augmented) of Positive_regulation (stimulation) of Thyrotrophin releasing hormone associated with narcan
10) Confidence 0.05 Published 1985 Journal Acta Endocrinol. Section Abstract Doc Link 2412379 Disease Relevance 0 Pain Relevance 0.65

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