INT233812

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Context Info
Confidence 0.77
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 18.15
Pain Relevance 6.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (PTH1R) plasma membrane (PTH1R) nucleus (PTH1R)
intracellular (PTH1R) cytoplasm (PTH1R) signal transducer activity (PTH1R)
Anatomy Link Frequency
chondrocytes 7
osteoblasts 5
hyaline cartilage 3
cartilage 3
plasma 2
PTH1R (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 1182 99.84 Very High Very High Very High
Inflammatory mediators 8 98.08 Very High Very High Very High
Inflammatory stimuli 17 96.08 Very High Very High Very High
Arthritis 50 94.44 High High
Pain 11 93.92 High High
Inflammation 108 93.56 High High
metalloproteinase 27 92.00 High High
antagonist 2 80.52 Quite High
Bioavailability 16 75.52 Quite High
COX2 8 75.00 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 1397 99.84 Very High Very High Very High
Disease 127 99.44 Very High Very High Very High
Apoptosis 72 98.60 Very High Very High Very High
INFLAMMATION 138 98.08 Very High Very High Very High
Frailty 22 95.24 Very High Very High Very High
Hypertrophy 43 95.12 Very High Very High Very High
Arthritis 59 94.44 High High
Pain 10 93.92 High High
Targeted Disruption 7 93.92 High High
Stress 31 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTH1R was expressed mainly in the middle zones of cartilage.
Gene_expression (expressed) of PTH1R in cartilage
1) Confidence 0.77 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 0.52 Pain Relevance 0.26
In contrast, PTH1R gene expression was depressed in sclerotic osteoblasts [24].
Gene_expression (expression) of PTH1R gene in osteoblasts
2) Confidence 0.77 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.02 Pain Relevance 0.34
In summary, the present study shows a decrease in the expression of the PTH1R receptor over the time course of OA.
Gene_expression (expression) of PTH1R receptor associated with osteoarthritis
3) Confidence 0.77 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 0.70 Pain Relevance 0.29
However, we confirmed that PTH1R is less expressed in OA cartilage with only a minority of cells expressing the receptor than in normal cartilage.
Gene_expression (expressed) of PTH1R in cartilage associated with osteoarthritis
4) Confidence 0.77 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.03 Pain Relevance 0.26
We could demonstrate a negative linear correlation between PTH1R expression and macroscopic and histologic grades in the early course of OA.
Gene_expression (expression) of PTH1R associated with osteoarthritis
5) Confidence 0.77 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.03 Pain Relevance 0.34
The present study was designed to evaluate the expression of the PTH1R on chondrocytes over the time course of experimentally induced secondary OA in an animal model as well as possible correlations between macroscopic and histologic findings in the degenerated hyaline cartilage.


Gene_expression (expression) of PTH1R in hyaline cartilage associated with osteoarthritis
6) Confidence 0.77 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.01 Pain Relevance 0.37
This is consistent with findings that as disease severity in OA progresses, PTH1R expression and protein levels are reduced in human subchondral osteoblasts.
Gene_expression (expression) of PTH1R in osteoblasts associated with disease and osteoarthritis
7) Confidence 0.77 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.07 Pain Relevance 0.35
Whereas the role of PTH1R in osteoarthritic chondrocytes remains largely unanswered, it was shown that as disease severity in OA progresses, PTH1R expression and protein levels are reduced in human subchondral osteoblasts [11].
Gene_expression (expression) of PTH1R in osteoblasts associated with disease and osteoarthritis
8) Confidence 0.77 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.36 Pain Relevance 0.39
A study to determine the influence of osteoarthritic phenotype of subchondral osteoblasts on the phenotype of human chondrocytes demonstrated that sclerotic osteoblasts, but not nonsclerotic osteoblasts induced a significant decrease of PTH1R gene expression in chondrocytes [25].
Gene_expression (expression) of PTH1R gene in osteoblasts associated with osteoarthritis
9) Confidence 0.77 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 0.97 Pain Relevance 0.34
Immunohistochemical method for labeling PTH1R
Gene_expression (labeling) of PTH1R
10) Confidence 0.67 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 0.20 Pain Relevance 0.05
Thus, it can be assumed that PTH1R participates in the underlying molecular mechanisms between cartilage degradation and subchondral bone remodelling and determines an important appearance in osteoarthritic progression.
Gene_expression (participates) of PTH1R in cartilage associated with osteoarthritis
11) Confidence 0.67 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.18 Pain Relevance 0.26
The results show an in vivo decrease in the expression of PTH1R on chondrocytes over the time course of OA.
Gene_expression (expression) of PTH1R in chondrocytes associated with osteoarthritis
12) Confidence 0.60 Published 2010 Journal J Orthop Surg Res Section Abstract Doc Link PMC2867974 Disease Relevance 0.56 Pain Relevance 0.21
The PTH1R is also highly expressed in the prehypertrophic chondrocytes of metaphyseal growth plates [4,5].
Gene_expression (expressed) of PTH1R in growth plates
13) Confidence 0.60 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 0.34 Pain Relevance 0.10
Immunostaining showed significantly less expression of PTH1R in the experimental compared to the control group after 6 (P < 0.05) and 12 weeks (P < 0.01).
Gene_expression (expression) of PTH1R
14) Confidence 0.60 Published 2010 Journal J Orthop Surg Res Section Abstract Doc Link PMC2867974 Disease Relevance 0.54 Pain Relevance 0.19
In the experimental group, a negative linear correlation between PTH1R expression and macroscopic and histologic grades was found.


Gene_expression (expression) of PTH1R
15) Confidence 0.60 Published 2010 Journal J Orthop Surg Res Section Abstract Doc Link PMC2867974 Disease Relevance 0.49 Pain Relevance 0.18
Our results confirm the expression of PTH1R in normal articular cartilage chondrocytes as detected by immunohistochemistry analysis [14].
Gene_expression (expression) of PTH1R in chondrocytes
16) Confidence 0.60 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 0.84 Pain Relevance 0.27
Decrease in the expression of the type 1 PTH/PTHrP receptor (PTH1R) on chondrocytes in animals with osteoarthritis

Background

Gene_expression (expression) of PTH1R in chondrocytes associated with osteoarthritis
17) Confidence 0.60 Published 2010 Journal J Orthop Surg Res Section Title Doc Link PMC2867974 Disease Relevance 0.60 Pain Relevance 0.22
Whereas the mechanisms of the type 1 PTH/PTHrP receptor (PTH1R) in osteoblasts were addressed in several studies [11,22-25], the expression of the PTH1R and its correlation with macroscopic and histologic features over the time course in a model of experimentally induced early OA are largely unknown.
Gene_expression (expression) of PTH1R in osteoblasts associated with osteoarthritis
18) Confidence 0.60 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 0.76 Pain Relevance 0.26
To evaluate the expression of the type 1 PTH/PTHrP receptor (PTH1R) on chondrocytes from hyaline cartilage over the course of osteoarthritis (OA).


Gene_expression (expression) of PTH1R in hyaline cartilage associated with osteoarthritis
19) Confidence 0.60 Published 2010 Journal J Orthop Surg Res Section Abstract Doc Link PMC2867974 Disease Relevance 0.53 Pain Relevance 0.18
PTHR-1 is abundantly expressed in bones and kidney and is known to play an important role in mediating PTH regulated mineral ion homeostasis and endochondral bone formation [68].
Gene_expression (expressed) of PTHR-1 in endochondral bone
20) Confidence 0.53 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0.33 Pain Relevance 0

General Comments

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