INT233816

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 4.08
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (PTH1R) plasma membrane (PTH1R) nucleus (PTH1R)
intracellular (PTH1R) cytoplasm (PTH1R) signal transducer activity (PTH1R)
Anatomy Link Frequency
osteoblasts 2
knee 1
PTH1R (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 153 99.74 Very High Very High Very High
metalloproteinase 3 49.36 Quite Low
Glutamate 11 26.08 Quite Low
chemokine 7 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Perioperative pain 3 5.00 Very Low Very Low Very Low
Cannabinoid receptor 2 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Somatostatin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 183 99.74 Very High Very High Very High
Disease 16 99.44 Very High Very High Very High
Diabetes Insipidus 1 98.84 Very High Very High Very High
Chondrodysplasia 1 93.56 High High
Sclerosis 3 92.72 High High
Hypercalcemia 2 88.68 High High
Osteophyte 15 86.36 High High
Hypertrophy 6 77.12 Quite High
Apoptosis 9 71.16 Quite High
Stress 4 70.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cases of severe, moderate, and mild OA patients who underwent total knee replacement surgery indicated a progressive decrease in PTH1R levels from -10% (mild) to -60% (severe) versus normal individuals [11].
Negative_regulation (decrease) of PTH1R in knee associated with osteoarthritis
1) Confidence 0.58 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.03 Pain Relevance 0.32
This is consistent with findings that as disease severity in OA progresses, PTH1R expression and protein levels are reduced in human subchondral osteoblasts.
Negative_regulation (reduced) of PTH1R in osteoblasts associated with disease and osteoarthritis
2) Confidence 0.43 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.09 Pain Relevance 0.35
Whereas the role of PTH1R in osteoarthritic chondrocytes remains largely unanswered, it was shown that as disease severity in OA progresses, PTH1R expression and protein levels are reduced in human subchondral osteoblasts [11].
Negative_regulation (reduced) of PTH1R in osteoblasts associated with disease and osteoarthritis
3) Confidence 0.43 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2867974 Disease Relevance 1.38 Pain Relevance 0.39
EST matches for CASR, PTHR1 and AVPR2 orthologs can be recovered in Ciona [Additional data file 2: Sheet 2].
Negative_regulation (recovered) of PTHR1
4) Confidence 0.29 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0.58 Pain Relevance 0

General Comments

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