INT233837

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 12.72
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Anatomy Link Frequency
epithelial cells 1
A549 1
Hif1a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 124 90.32 High High
COX2 42 83.44 Quite High
cytokine 8 81.52 Quite High
Kinase C 1 38.72 Quite Low
withdrawal 10 29.28 Quite Low
Inflammatory response 6 29.12 Quite Low
ischemia 25 17.28 Low Low
imagery 29 5.00 Very Low Very Low Very Low
chemokine 14 5.00 Very Low Very Low Very Low
ketamine 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 42 100.00 Very High Very High Very High
Infection 535 99.52 Very High Very High Very High
Respiratory Syncytial Virus 594 99.32 Very High Very High Very High
Lung Cancer 40 98.72 Very High Very High Very High
Hypoxia 218 97.68 Very High Very High Very High
Non-small-cell Lung Cancer 28 95.76 Very High Very High Very High
Cancer 145 94.76 High High
Body Weight 10 93.24 High High
INFLAMMATION 123 90.32 High High
Metastasis 13 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This prevents the HIF-1?
Negative_regulation (prevents) of HIF-1
1) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.30 Pain Relevance 0
The destabilization of HIF-1?
Negative_regulation (destabilization) of HIF-1
2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.35 Pain Relevance 0
Another oxygen dependent control acting to limit the activity of HIF-1?
Negative_regulation (limit) of HIF-1
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.32 Pain Relevance 0
Re-inhibition of HIF-1?
Negative_regulation (inhibition) of HIF-1
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.44 Pain Relevance 0
Substitution of Pro564 and Pro402 abrogates HIF-1?
Negative_regulation (abrogates) of HIF-1
5) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.27 Pain Relevance 0
HIF-dependent gene expression during RSV infection in pulmonary epithelial cells following siRNA repression of HIF-1?
Negative_regulation (repression) of HIF-1 in epithelial cells associated with repression, infection and respiratory syncytial virus
6) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.89 Pain Relevance 0.08
target genes was induced following RSV infection, while siRNA-dependent repression of HIF-1?
Negative_regulation (repression) of HIF-1 associated with repression, infection and respiratory syncytial virus
7) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 2.10 Pain Relevance 0.11
subunit, while oxygen deprivation stabilizes and enhances HIF-1?
Negative_regulation (deprivation) of HIF-1
8) Confidence 0.18 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2902148 Disease Relevance 0.62 Pain Relevance 0.08
Repression of HIF-1?
Negative_regulation (Repression) of HIF-1 associated with repression
9) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 0.35 Pain Relevance 0.07
To demonstrate effective repression of HIF-1?
Negative_regulation (repression) of HIF-1 associated with repression
10) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.36 Pain Relevance 0.06
dependent gene induction was abolished in pulmonary epithelia following siRNA mediated repression of HIF-1?.
Negative_regulation (repression) of HIF-1 associated with repression
11) Confidence 0.16 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2556398 Disease Relevance 2.02 Pain Relevance 0.07
For this purpose, we generated a pulmonary epithelial cell line (A549 cells) with stable repression of HIF-1?.
Negative_regulation (repression) of HIF-1 in A549 associated with repression
12) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.45 Pain Relevance 0.07
has been shown to inhibit HIF-1 in other systems [45].
Negative_regulation (inhibit) of HIF-1
13) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 1.26 Pain Relevance 0.12

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