INT233845

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.81
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Itk) kinase activity (Itk) cytoplasm (Itk)
Anatomy Link Frequency
nucleus 1
nodules 1
Itk (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 13 98.56 Very High Very High Very High
chemokine 3 93.68 High High
cytokine 13 64.24 Quite High
Pain 2 45.16 Quite Low
Inflammation 14 19.60 Low Low
imagery 17 5.00 Very Low Very Low Very Low
Neuropeptide 12 5.00 Very Low Very Low Very Low
cINOD 9 5.00 Very Low Very Low Very Low
Cholecystokinin 3 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 393 99.44 Very High Very High Very High
Carcinoma 22 99.44 Very High Very High Very High
Lung Cancer 148 97.40 Very High Very High Very High
Apoptosis 23 96.08 Very High Very High Very High
Metastasis 187 93.36 High High
Breast Cancer 118 87.28 High High
Non-small-cell Lung Cancer 77 75.68 Quite High
Adhesions 3 74.80 Quite High
Bone Cancer 4 65.80 Quite High
Colon Cancer 15 61.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
antagonists during chemotherapy may sensitize carcinoma cells, in part through the inhibition of EMT, to the anti-tumor and anti-metastatic activities of chemotherapy resulting in increased therapeutic efficacy and reduced dosage of chemotherapeutics and their unwanted side effects.


Negative_regulation (inhibition) of EMT associated with cancer, antagonist and carcinoma
1) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 1.37 Pain Relevance 0.05
RI-KI was included in the treatment, suggesting the inhibition of EMT as indicated by the re-expression of F-actin along cell membrane and a more even distribution of Snail between cytoplasm and nucleus (Figure 3C).
Negative_regulation (inhibition) of EMT in nucleus
2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.08 Pain Relevance 0
part through inhibiting or reversing EMT.
Negative_regulation (inhibiting) of EMT
3) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.93 Pain Relevance 0.06
blocking EMT.
Negative_regulation (blocking) of EMT
4) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.81 Pain Relevance 0.05
part through inhibiting or reversing EMT.
Negative_regulation (reversing) of EMT
5) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.92 Pain Relevance 0.06
Our data show that, to some extent, the expression levels of some EMT markers became switched between the pulmonary metastatic nodules and the primary SPC-A-1sci tumour, as determined by immunohistochemical analysis.
Negative_regulation (switched) of EMT in nodules associated with cancer
6) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912267 Disease Relevance 0.39 Pain Relevance 0
MEK1 blocked EMT induced by PPAR?
Negative_regulation (blocked) of EMT
7) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.31 Pain Relevance 0

General Comments

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