INT233911

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.66
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nfatc1) DNA binding (Nfatc1) cytoplasm (Nfatc1)
Anatomy Link Frequency
myocyte 1
heart 1
Nfatc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 22 97.44 Very High Very High Very High
cytokine 3 96.40 Very High Very High Very High
fibrosis 14 85.56 High High
agonist 25 79.20 Quite High
psoriasis 1 68.40 Quite High
Glutamate 1 55.36 Quite High
palliative 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arrhythmia Under Development 39 98.96 Very High Very High Very High
Embryonic Lethality 3 97.56 Very High Very High Very High
INFLAMMATION 22 97.44 Very High Very High Very High
Death 10 97.12 Very High Very High Very High
Hypertrophy 7 92.64 High High
Apoptosis 6 90.00 High High
Cv General 4 Under Development 3 89.16 High High
Diabetes Mellitus 29 86.88 High High
Pressure And Volume Under Development 20 86.40 High High
Fibrosis 11 85.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is not clear whether loss of NFAT activity in the heart is directly responsible for this effect or one of many other targets of calcineurin that are NFAT-independent.
Spec (whether) Negative_regulation (loss) of NFAT in heart
1) Confidence 0.54 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.54 Pain Relevance 0.08
Moreover, calcineurin-NFAT signaling is already known to be required for valve formation as loss of Nfatc1 in gene-deleted mice causes prominent defects in valves and embryonic lethality (41, 42).
Negative_regulation (loss) of Nfatc1 associated with embryonic lethality
2) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.21 Pain Relevance 0
It is more likely that the loss of calcineurin-NFAT signaling leads to primary defects in cardiac function and arrhythmia (death) by subtly altering the differentiated state of the cardiac myocyte such that select genes necessary for efficient myocyte contraction are not properly expressed.
Negative_regulation (loss) of NFAT in myocyte associated with arrhythmia under development and death
3) Confidence 0.39 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.57 Pain Relevance 0
B, AP-1, STAT, NFAT), and inhibiting the activity and
Negative_regulation (inhibiting) of NFAT
4) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 1.34 Pain Relevance 0.30

General Comments

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