INT233916

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.67
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (AGTR2) signal transducer activity (AGTR2)
Anatomy Link Frequency
coronary artery 1
heart 1
AGTR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
beta blocker 20 97.56 Very High Very High Very High
Inflammation 24 91.68 High High
fibrosis 6 91.00 High High
antidepressant 4 87.24 High High
bradykinin 1 86.04 High High
Bioavailability 3 59.52 Quite High
headache 3 54.60 Quite High
Onset of action 2 51.28 Quite High
agonist 19 50.00 Quite Low
Calcium channel 7 32.92 Quite Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 134 100.00 Very High Very High Very High
Natriuresis 2 99.40 Very High Very High Very High
Renal Disease 56 98.56 Very High Very High Very High
Increased Venous Pressure Under Development 17 97.56 Very High Very High Very High
Cv General 4 Under Development 5 97.08 Very High Very High Very High
Pressure And Volume Under Development 101 95.72 Very High Very High Very High
INFLAMMATION 27 91.68 High High
Coronary Artery Disease 10 91.04 High High
Fibrosis 6 91.00 High High
Heart Rate Under Development 25 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Seven drug classes used for the treatment of 12 indications received a rating of high-quality : (1) Angiotensin converting enzyme inhibitors (ACE-inhibitors) in patients with chronic heart failure; (2) angiotensin II receptor blockers (ARBs) in patients with chronic heart failure; (3) beta-blockers for patients with myocardial infarction and for patients with left ventricular systolic dysfunction; (4) newer antiplatelet agents for patients with coronary artery disease; (5) statins in persons with hypercholesteremia; (6) second-generation antidepressants for the treatment of major depressive disorder; and (7) newer antiemetic agents for the prevention of chemotherapy-induced nausea and emesis.
Positive_regulation (received) of angiotensin II receptor in coronary artery associated with antidepressant, depression, coronary artery disease, beta blocker, vomiting, hypercholesterolemia and myocardial infarction
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912767 Disease Relevance 0.88 Pain Relevance 0.09
The degree of AT2 stimulation is proportional to the selectivity of AT1 blockade.12
Positive_regulation (stimulation) of AT2
2) Confidence 0.31 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.43 Pain Relevance 0.06
In patients taking ACE-inhibitors, the blunted production of angiotensin II and the consequent reduced stimulation of AT1- and AT2 receptor may induce an ‘escape phenomenon’, which consists in the accumulation of angiotensin I and production of angiotensin II through alternative synthetic bio-pathways (cathepsine C, chimases).10 This phenomenon, well described in patients with congestive heart failure, may be prognostically important.
Positive_regulation (stimulation) of AT2 in heart associated with heart rate under development
3) Confidence 0.25 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.96 Pain Relevance 0.13
In the kidneys, especially at the renal tubular level, the stimulation of AT2 could mediate natriuresis which could also contribute to the antihypertensive effect.26,27 Stopping valsartan intake is not associated with rebound of the BP level.


Positive_regulation (stimulation) of AT2 associated with natriuresis
4) Confidence 0.19 Published 2010 Journal Core evidence Section Body Doc Link PMC2899780 Disease Relevance 0.41 Pain Relevance 0.15
AT2-R activation generally has beneficial effects,
Positive_regulation (activation) of AT2
5) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 0.98 Pain Relevance 0.08

General Comments

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