INT233943

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.79
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Expi) molecular_function (Expi) cellular_component (Expi)
biological_process (Expi)
Anatomy Link Frequency
plasma 2
nerve 1
Expi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Acupuncture 80 98.64 Very High Very High Very High
imagery 34 95.12 Very High Very High Very High
fibrosis 37 94.24 High High
Sciatic nerve 55 91.56 High High
visual analogue scale 7 79.44 Quite High
dysesthesia 35 77.64 Quite High
Pain 50 77.00 Quite High
electroacupuncture 68 75.00 Quite High
tolerance 40 56.76 Quite High
backache 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 38 94.24 High High
Cicatrix 16 90.08 High High
Myocardial Infarction 15 87.60 High High
Pulmonary Fibrosis 5 84.16 Quite High
Dysesthesia 35 77.64 Quite High
Pain 46 77.00 Quite High
Atherosclerotic Plaque 2 76.08 Quite High
Low Back Pain 28 75.00 Quite High
Pathologic Constriction 18 67.80 Quite High
Coronary Heart Disease 1 16.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a subsequent series of papers we will demonstrate how multiple rates and durations of intravenous dosing, coupled to observations of pharmacology during and after the provocations (washout), may help to elucidate the rate limiting steps behind a physiological turnover system exhibiting rapid adaptation.We also advocate ex vivo plasma protein binding of the test compound for appropriate estimation of unbound exposure, since changes in plasma protein binding have been shown to affect the exponent (Hill coefficient) in the sigmoid Emax model when converting total to unbound concentrations.
ex vivo Binding (binding) of in plasma
1) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2751452 Disease Relevance 0 Pain Relevance 0.03
Ex vivo plasma protein binding has, in our experience, given different results compared to pooled in vitro plasma protein binding experiments.
Ex vivo Binding (binding) of in plasma
2) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2751452 Disease Relevance 0 Pain Relevance 0
EA on the pudendal nerve was effective for the symptoms which had not improved by Ex-B2.
Ex-B2 Binding (improved) of in nerve associated with acupuncture
3) Confidence 0.02 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2396470 Disease Relevance 0.36 Pain Relevance 1.08
This peptide, designated collagelin, exhibits collagen-binding properties both in vitro and ex vivo.
ex vivo Binding (binding) of
4) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680759 Disease Relevance 0.43 Pain Relevance 0.22

General Comments

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