INT233970

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.20
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Myd88) signal transduction (Myd88) plasma membrane (Myd88)
intracellular (Myd88) protein complex (Myd88) cytoplasm (Myd88)
Anatomy Link Frequency
articular 1
A20 1
brain 1
Myd88 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 1 100.00 Very High Very High Very High
Arthritis 15 99.52 Very High Very High Very High
Inflammation 150 98.70 Very High Very High Very High
antagonist 7 98.40 Very High Very High Very High
cytokine 70 97.96 Very High Very High Very High
tolerance 45 86.72 High High
rheumatoid arthritis 70 85.84 High High
fibrosis 2 78.00 Quite High
Inflammatory mediators 9 69.48 Quite High
chemokine 21 60.20 Quite High
Disease Link Frequency Relevance Heat
Injury 133 99.64 Very High Very High Very High
Arthritis 19 99.52 Very High Very High Very High
Diabetes Mellitus 71 99.40 Very High Very High Very High
Aging 3 99.28 Very High Very High Very High
INFLAMMATION 169 98.70 Very High Very High Very High
Vasculitis 8 97.04 Very High Very High Very High
Targeted Disruption 14 96.80 Very High Very High Very High
Pressure And Volume Under Development 2 92.20 High High
Systemic Lupus Erythematosus 62 90.40 High High
Disease 73 87.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data also do not directly contradict the recent report that Myd88?
Neg (not) Regulation (contradict) of Myd88
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666970 Disease Relevance 0.80 Pain Relevance 0
Flow-induced superoxide generation is dependent on MyD88
Regulation (dependent) of MyD88
2) Confidence 0.43 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.22 Pain Relevance 0.26
Myd88 and Tollip, both significantly downregulated by HOXA3 treatment, encode central components of the NF-?
Regulation (downregulated) of Myd88
3) Confidence 0.35 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 1.07 Pain Relevance 0.15
Currently, active research on this topic is concerned with negatively regulating molecules that activate TLR-dependent signaling, but what about activating some of the natural inhibitory proteins, such as Triad3A, MyD88s, SHP-1, IRAK-M, IRAK1c, IRF4, and A20?
Regulation (some) of MyD88s in A20
4) Confidence 0.32 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.63 Pain Relevance 0.08
Furthermore, intra-articular administration of peptidoglycan or lipopolysaccharide, the ligands for TLR2 and TLR4, respectively, results in destructive arthritis in mice, which is also dependent on MyD88 [45,46].
Regulation (dependent) of MyD88 in articular associated with arthritis
5) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 1.06 Pain Relevance 0.37
Nevertheless, injuries subsequent to the degenerative process progressively created a chronic inflammatory state in the brain of ageing MPSIIIB mice (8 months), which was independent of TLR4 and MyD88, and which in turn may have exacerbated pathology.
Neg (independent) Regulation (independent) of MyD88 in brain associated with aging, inflammation and injury
6) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 1.22 Pain Relevance 0.20
Specifically, PKR was shown to interact directly with the TLR4 adapter TIRAP/Mal and to exhibit a partial dependence on MyD88 for activation through TLR4 (24).
Spec (partial) Regulation (dependence) of MyD88 associated with addiction
7) Confidence 0.13 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.19 Pain Relevance 0.22

General Comments

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