INT233973

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.32
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Myd88) signal transduction (Myd88) plasma membrane (Myd88)
intracellular (Myd88) protein complex (Myd88) cytoplasm (Myd88)
Anatomy Link Frequency
brain 4
microglial cell 2
Myd88 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 42 99.80 Very High Very High Very High
cytokine 50 96.80 Very High Very High Very High
Inflammation 127 92.72 High High
imagery 6 65.72 Quite High
cINOD 15 34.20 Quite Low
Central nervous system 9 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 203 97.88 Very High Very High Very High
INFLAMMATION 119 92.72 High High
Cognitive Disorder 4 77.88 Quite High
Targeted Disruption 20 57.08 Quite High
Mucopolysaccharidoses 9 50.00 Quite Low
Neurodegenerative Disease 25 37.24 Quite Low
Meningoencephalitis 22 28.60 Quite Low
Immunization 30 25.32 Quite Low
Death 9 15.64 Low Low
Intellectual Impairment 6 14.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
agonist 15d-PGJ2 suppressed microglial expression of MyD88 and CD14
Negative_regulation (suppressed) of Gene_expression (expression) of MyD88 associated with agonist
1) Confidence 0.38 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.62 Pain Relevance 0.26
With the aim to examine relationships between microglial cell priming by HS oligosaccharides and the progression of neuroinflammation and neurodegeneration in the brain with age, we studied MPSIIIB mice and produced MPSIIIB mice deficient for the expression of TLR4 or MyD88.
Negative_regulation (deficient) of Gene_expression (expression) of MyD88 in brain
2) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0 Pain Relevance 0
Absence of NaGlu, TLR4 or MyD88 expression was verified in brain extracts (table S1).
Negative_regulation (Absence) of Gene_expression (expression) of MyD88 in brain
3) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0 Pain Relevance 0.03
Microglial cell activation was much less intense when microglial cell cultures were derived from mice deficient for the expression of the innate immune response receptor Toll Like Receptor (TLR) 4 or the TLR adaptor protein MyD88 (figure 1).
Negative_regulation (deficient) of Gene_expression (expression) of MyD88 in microglial cell
4) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0 Pain Relevance 0
demonstrate that 15d-PGJ2 inhibits the expression of MyD88-dependent
Negative_regulation (inhibits) of Gene_expression (expression) of MyD88-dependent
5) Confidence 0.28 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.71 Pain Relevance 0.33

General Comments

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