INT234

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Context Info
Confidence 0.48
First Reported 1976
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 151
Total Number 154
Disease Relevance 52.34
Pain Relevance 32.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Alb) extracellular space (Alb) extracellular region (Alb)
enzyme binding (Alb) DNA binding (Alb) protein complex (Alb)
Anatomy Link Frequency
plasma 32
blood 6
liver 5
brain 4
red blood cell 3
Alb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 177 100.00 Very High Very High Very High
Pain 131 100.00 Very High Very High Very High
ischemia 109 100.00 Very High Very High Very High
corticosteroid 23 100.00 Very High Very High Very High
Codeine 12 100.00 Very High Very High Very High
diclofenac 96 99.98 Very High Very High Very High
lidocaine 60 99.98 Very High Very High Very High
rapifen 7 99.98 Very High Very High Very High
halothane 181 99.88 Very High Very High Very High
Inflammation 315 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 449 100.00 Very High Very High Very High
Pain 160 100.00 Very High Very High Very High
Cancer 152 100.00 Very High Very High Very High
Appetite Loss 102 100.00 Very High Very High Very High
Chronic Renal Failure 97 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 95 100.00 Very High Very High Very High
Cv Unclassified Under Development 94 100.00 Very High Very High Very High
Obesity 91 100.00 Very High Very High Very High
Disease 132 99.98 Very High Very High Very High
Nephrotoxicity 3 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The [3H]acetaminophen sulfate, which binds partially to albumin, emerged between albumin and sucrose in the presence of albumin, processed the upslope of the sucrose curve and showed a late low-in-magnitude tailing; the precession disappeared in the absence of albumin.
albumin Binding (binds) of associated with paracetamol
1) Confidence 0.48 Published 1992 Journal Hepatology Section Abstract Doc Link 1618470 Disease Relevance 0 Pain Relevance 0.53
Quantitative evaluation with a barrier-limited, space-distributed variable transit time model (including rapidly equilibrating albumin binding) accounted for the albumin effect on [3H]acetaminophen sulfate behavior and demonstrated a low liver cell permeability for the acetaminophen sulfate and a small interstitial binding space for its nonalbumin-bound fraction in excess of that for sucrose, which in the absence of albumin was of similar dimensions.
albumin Binding (binding) of in liver associated with paracetamol
2) Confidence 0.48 Published 1992 Journal Hepatology Section Abstract Doc Link 1618470 Disease Relevance 0 Pain Relevance 0.57
Because acetaminophen is avidly bound to red blood cells and not albumin, a pre-equilibrated MID dose containing the noneliminated references (51Cr-labeled red blood cells [RBC, a vascular reference], [58Co]EDTA [a small molecular weight interstitial reference that does not enter cells], and D2O [a cellular reference]) and [3H]-acetaminophen was introduced into the portal vein of the single-pass perfused rat liver (1 mg/L acetaminophen) under varying conditions of hematocrit, with observation of timed outflow profiles in the hepatic venous blood.
albumin Binding (bound) of in portal vein associated with paracetamol
3) Confidence 0.48 Published 1995 Journal Hepatology Section Abstract Doc Link 7601421 Disease Relevance 0 Pain Relevance 0.60
Brainstem auditory evoked potential (BAEP) abnormalities occur in jaundiced Gunn rats given sulfadimethoxine to displace bilirubin bound to serum albumin, releasing it into the tissues.
serum albumin Binding (bound) of in Brainstem associated with medulla, congenital anomalies and jaundice
4) Confidence 0.48 Published 2006 Journal Brain Res. Section Abstract Doc Link 16828065 Disease Relevance 0.35 Pain Relevance 0.25
In contrast, the KaD value of albumin binding of tryptophan in vivo in the rabbit brain microcirculation was reduced by ether anesthesia to a value of 2.1 +/- 0.4 mM.
albumin Binding (binding) of in brain associated with anesthesia
5) Confidence 0.48 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2303823 Disease Relevance 0 Pain Relevance 0.35
This hypothesis was confirmed in the present studies wherein the dissociation constant (KaD) of albumin binding of tryptophan in the rat or rabbit brain microcirculation was measured in vivo.
albumin Binding (binding) of in brain
6) Confidence 0.48 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2303823 Disease Relevance 0 Pain Relevance 0.07
The KaD of albumin binding in the rat or rabbit brain microcirculation under pentobarbital anesthesia was 1.7 +/- 0.1 and 3.9 +/- 1.0 mM, respectively, as compared to the KD value measured in vitro with equilibrium dialysis, 0.13 +/- 0.03 mM.
albumin Binding (binding) of in brain associated with anesthesia
7) Confidence 0.48 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2303823 Disease Relevance 0 Pain Relevance 0.24
Tryptophan is the only amino acid in the circulation that is bound by albumin, and previous studies have suggested that the brain tryptophan supply is a function of either the free or the albumin-bound pool of tryptophan in blood.
albumin Binding (bound) of in brain
8) Confidence 0.48 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2303823 Disease Relevance 0 Pain Relevance 0
Assuming binding only to albumin, the data were fitted to a model of two classes of binding sites with dissociation constants K1 and K2.
albumin Binding (binding) of
9) Confidence 0.47 Published 1997 Journal J Pharmacokinet Biopharm Section Abstract Doc Link 9353694 Disease Relevance 0.07 Pain Relevance 0.41
Bromfenac binds extensively to plasma albumin.
albumin Binding (binds) of in plasma
10) Confidence 0.47 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427465 Disease Relevance 0.28 Pain Relevance 0.22
Sulindac and its sulphide and sulphone metabolites bind extensively to plasma albumin.
albumin Binding (bind) of in plasma
11) Confidence 0.47 Published 1997 Journal Clin Pharmacokinet Section Abstract Doc Link 9195115 Disease Relevance 0.40 Pain Relevance 0.31
Lornoxicam and its metabolites bind extensively to plasma albumin.
albumin Binding (bind) of in plasma
12) Confidence 0.47 Published 1998 Journal Clin Pharmacokinet Section Abstract Doc Link 9646006 Disease Relevance 0.27 Pain Relevance 0.29
Naproxen binds extensively, in a concentration-dependent manner, to plasma albumin.
albumin Binding (binds) of in plasma
13) Confidence 0.47 Published 1997 Journal Clin Pharmacokinet Section Abstract Doc Link 9113437 Disease Relevance 0.16 Pain Relevance 0.16
Tiaprofenic acid binds extensively to plasma albumin.
albumin Binding (binds) of in plasma
14) Confidence 0.47 Published 1996 Journal Clin Pharmacokinet Section Abstract Doc Link 9118583 Disease Relevance 0.12 Pain Relevance 0.14
Diclofenac binds extensively to plasma albumin.
albumin Binding (binds) of in plasma associated with diclofenac
15) Confidence 0.47 Published 1997 Journal Clin Pharmacokinet Section Abstract Doc Link 9314611 Disease Relevance 0.09 Pain Relevance 0.57
Historically, attempts to group this heterogeneous class of compounds into a single entity are largely derived from the observation that the majority of clinically useful NSAIDs are weak organic acids (pKa 3 to 5), bind extensively to plasma albumin (= 99%), and inhibit (to varying degrees) prostaglandin synthesis.
albumin Binding (bind) of in plasma associated with cinod
16) Confidence 0.47 Published 1994 Journal Drugs Section Abstract Doc Link 7525183 Disease Relevance 0.85 Pain Relevance 1.25
Ketoprofen binds extensively to plasma albumin, apparently in a stereoselective manner.
albumin Binding (binds) of in plasma
17) Confidence 0.47 Published 1990 Journal Clin Pharmacokinet Section Abstract Doc Link 2203580 Disease Relevance 0.06 Pain Relevance 0.28
A review is presented of recent progress in bilirubin chemistry, its binding to albumin, displacement by drugs, and the mechanism of phototherapy.
albumin Binding (binding) of
18) Confidence 0.47 Published 1977 Journal Acta Paediatr Scand Section Abstract Doc Link 19921 Disease Relevance 0.07 Pain Relevance 0
Oral risperidone undergoes significant ‘first-pass’ metabolism – 90% is bound in plasma to albumin and alpha-1 acid glycoprotein prior to elimination via the kidneys.
albumin Binding (bound) of in plasma
19) Confidence 0.47 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938294 Disease Relevance 0.15 Pain Relevance 0
These variations may indicate that complex metabolic and biochemical events influenced the calcium binding to albumin and the calcium transfer into the muscle cells.
albumin Binding (binding) of in muscle cells
20) Confidence 0.46 Published 1989 Journal Acta Anaesthesiol Belg Section Abstract Doc Link 2816245 Disease Relevance 0.33 Pain Relevance 0.22

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