INT234003

Context Info Confidence 0.10 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 2.33 Pain Relevance 0.58

chromosome segregation (RIOK3) kinase activity (RIOK3)

RIOK3 (Homo sapiens)

Pain Link Frequency Relevance Heat Buprenorphine 21 90.40 opiate 18 88.16 alcohol 6 80.88 methadone 9 75.24 cannabis 9 51.64 addiction 33 27.76 withdrawal 9 10.52 depression 3 5.00 agonist 3 5.00 Thalamus 3 5.00

Disease Link Frequency Relevance Heat Drug Dependence 165 100.00 Diabetes Mellitus 12 99.10 Epilepsy 15 89.76 Injury 99 83.44 Opiate Addiction 3 78.40 Aggression 3 71.80 Attention Deficit Hyperactivity Disorder 3 33.04 Bone Fracture 3 5.92 Syndrome 6 5.76 Acquired Immune Deficiency Syndrome Or Hiv Infection 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed the very large degree to which many of the relevant pathologies were elevated amongst the SUD group had not been foreseen.

Positive_regulation (elevated) of SUD associated with drug dependence

1) Confidence 0.10 Published 2008 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2396610 Disease Relevance 0.53 Pain Relevance 0.24

These differences did not appear to be related to untoward rates of medical conditions in SUD patients, and the rate of visual impairment, wearing of spectacles, diabetes and insulin use were found either not to be elevated in the SUD group, or the differences suggested the SUD group enjoyed better health.

Positive_regulation (elevated) of SUD associated with drug dependence and diabetes mellitus

2) Confidence 0.09 Published 2008 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2396610 Disease Relevance 1.14 Pain Relevance 0.12

When all nine of these drug use categories were considered together in a sequential Chi-squared analysis there was significant elevation of drug use in the SUD group overall (Chi Squ. = 455.38, df = 8, O.R. = 10.07, 95% C.I. 8.80–14.72, P < 0.0001).

Positive_regulation (elevation) of SUD associated with drug dependence

3) Confidence 0.09 Published 2008 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2396610 Disease Relevance 0.66 Pain Relevance 0.22

General Comments

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