INT23402

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Context Info
Confidence 0.48
First Reported 1983
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 74
Total Number 76
Disease Relevance 52.01
Pain Relevance 10.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DOA) plasma membrane (HLA-DOA)
Anatomy Link Frequency
leukocyte 8
T cell 5
lymphocytes 2
groove 1
hematopoietic stem cell 1
HLA-DOA (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 297 100.00 Very High Very High Very High
psoriasis 80 100.00 Very High Very High Very High
postherpetic neuralgia 56 99.80 Very High Very High Very High
Rsd 4 99.76 Very High Very High Very High
spinal inflammation 63 99.52 Very High Very High Very High
neuralgia 12 99.04 Very High Very High Very High
rheumatoid arthritis 209 98.92 Very High Very High Very High
Serotonin 14 96.56 Very High Very High Very High
Pain 43 96.20 Very High Very High Very High
Fibrositis 40 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 958 100.00 Very High Very High Very High
Multiple Sclerosis 101 100.00 Very High Very High Very High
Psoriasis 99 100.00 Very High Very High Very High
Sleep Disorders 36 100.00 Very High Very High Very High
Autoimmune Disease 237 99.98 Very High Very High Very High
Drug Hypersensitivity 5 99.92 Very High Very High Very High
Post Operative Pain 56 99.80 Very High Very High Very High
Communicable Diseases 9 99.76 Very High Very High Very High
Reflex Sympathetic Dystrophy 6 99.76 Very High Very High Very High
Low Back Pain 63 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The human histocompatibility leukocyte antigen (HLA) haplotype is associated with the onset of postherpetic neuralgia after herpes zoster.
HLA Binding (associated) of in leukocyte associated with neuralgia, herpes zoster and postherpetic neuralgia
1) Confidence 0.48 Published 2004 Journal Pain Section Title Doc Link 15275783 Disease Relevance 1.61 Pain Relevance 1.28
To distinguish whether the haplotype is associated with herpes zoster or the development of PHN, we examined if herpes zoster patients without subsequently PHN are also associated with the HLA haplotype or not.
HLA Spec (examined) Binding (associated) of associated with herpes zoster and postherpetic neuralgia
2) Confidence 0.48 Published 2004 Journal Pain Section Abstract Doc Link 15275783 Disease Relevance 1.82 Pain Relevance 1.07
We have recently reported the association of the human histocompatibility leukocyte antigens (HLA) haplotype, HLA-A*3303-B*4403-DRB1*1302 with PHN patients; however, it has not been determined whether the haplotype is also associated with herpes zoster that did not develop subsequent PHN.
HLA Binding (association) of in leukocyte associated with herpes zoster and postherpetic neuralgia
3) Confidence 0.37 Published 2004 Journal Pain Section Abstract Doc Link 15275783 Disease Relevance 1.37 Pain Relevance 0.82
We have recently reported the association of the human histocompatibility leukocyte antigens (HLA) haplotype, HLA-A*3303-B*4403-DRB1*1302 with PHN patients; however, it has not been determined whether the haplotype is also associated with herpes zoster that did not develop subsequent PHN.
HLA Binding (association) of in leukocyte associated with herpes zoster and postherpetic neuralgia
4) Confidence 0.37 Published 2004 Journal Pain Section Abstract Doc Link 15275783 Disease Relevance 1.36 Pain Relevance 0.82
This endows the system with unique differentiating powers, both in terms of the population genetics of the reconstruction of evolutionary trees to assess biological divergences (or affinities) in human populations, and in terms of detecting the genetic component of the many diseases which show an association with certain variants (alleles) of the HLA system.
HLA Binding (association) of associated with disease
5) Confidence 0.32 Published 1983 Journal Am. J. Phys. Anthropol. Section Abstract Doc Link 6624903 Disease Relevance 0.51 Pain Relevance 0.07
Different racial groups often exhibit different HLA disease associations; that is, a different allele is associated with the disease in different populations, although in some cases the same allele is associated with the disease in all populations.
HLA Binding (associations) of associated with disease
6) Confidence 0.27 Published 1983 Journal Am. J. Phys. Anthropol. Section Abstract Doc Link 6624903 Disease Relevance 0.54 Pain Relevance 0.08
OBJECTIVES: To test possible human lymphocyte antigen (HLA) associations in subjects with reflex sympathetic dystrophy (RSD), and to determine correlation of HLA associations to treatment outcomes.
HLA Binding (associations) of in sympathetic associated with rsd and reflex sympathetic dystrophy
7) Confidence 0.21 Published 1994 Journal Clin J Pain Section Abstract Doc Link 7833579 Disease Relevance 0.35 Pain Relevance 0.17
OBJECTIVES: To test possible human lymphocyte antigen (HLA) associations in subjects with reflex sympathetic dystrophy (RSD), and to determine correlation of HLA associations to treatment outcomes.
HLA Binding (associations) of in lymphocyte associated with rsd and reflex sympathetic dystrophy
8) Confidence 0.21 Published 1994 Journal Clin J Pain Section Abstract Doc Link 7833579 Disease Relevance 0.35 Pain Relevance 0.17
There was also a significant interaction between HLA-Cw1 and sex (p = 0.03, logistic regression).
HLA Binding (interaction) of
9) Confidence 0.21 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.13 Pain Relevance 0
Human lymphocyte antigen (HLA)-Bw51, HLA-B27, and HLA-B12 have each been associated with various manifestations of Beh├žet's disease.
HLA Binding (associated) of in B12 associated with disease
10) Confidence 0.17 Published 1988 Journal J. Am. Acad. Dermatol. Section Abstract Doc Link 3056991 Disease Relevance 1.12 Pain Relevance 0.18
Both T-cell and B-cell (antibody) immune responses are important in graft rejection.29 T lymphocytes recognize donor cell-derived peptides in association with the HLA molecules on the graft.30 CD4+ T helper cells are activated by antigen-presenting cells (APC) carrying HLA class II molecules.
HLA Binding (association) of in T-cell associated with graft vs host disease
11) Confidence 0.16 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.16 Pain Relevance 0
The exact mechanisms underlying the most HLA-disease association are not well understood, and other genetic and environmental factors may play roles as well.
HLA-disease Binding (association) of associated with disease
12) Confidence 0.14 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 1.25 Pain Relevance 0.12
Previously the unidentified disease gene had been postulated to be closely linked to the HLA-A locus, especially on the HLA-A3 haplotype.
HLA Binding (linked) of associated with disease
13) Confidence 0.12 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 1.27 Pain Relevance 0.10
Recent clinical data indicate that HLA-C matching also affects the clinical outcomes of hematopoietic stem cell transplantation, but HLA-DQ and HLA-DP do not appear critical.27,28
HLA Binding (matching) of in hematopoietic stem cell
14) Confidence 0.12 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.22 Pain Relevance 0
If the specificity of the patient's antibodies can be determined, donors who are negative for corresponding HLA antigens can be selected.
HLA Binding (negative) of
15) Confidence 0.12 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.28 Pain Relevance 0
Among the most prominent associations are narcolepsy with HLA-DQB1*0602/HLA-DRB1*1501, ankylosing spondylitis with HLA-B27, and celiac disease with HLA-DQB1*02.
HLA Binding (narcolepsy) of associated with spinal inflammation, celiac disease and sleep disorders
16) Confidence 0.12 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 1.39 Pain Relevance 0.14
Previously the unidentified disease gene had been postulated to be closely linked to the HLA-A locus, especially on the HLA-A3 haplotype.
HLA Binding (linked) of associated with disease
17) Confidence 0.12 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 1.26 Pain Relevance 0.10
Severe aplastic anemia patients who had developed HLA alloimmunization have a higher incidence of graft rejection following stem cell transplantations.57
HLA Binding (alloimmunization) of in stem cell associated with aplastic anemia and graft vs host disease
18) Confidence 0.12 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.41 Pain Relevance 0
This is the first study to demonstrate a positive association between an HLA allele and the AIU phenotype.
HLA Binding (association) of associated with pressure and volume under development
19) Confidence 0.12 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 1.54 Pain Relevance 0.17
The peptide-binding specificities of HLA molecules are determined by a limited number of amino acid residues located in the peptide-binding pockets.13 Different HLA molecules show characteristic amino acid residue patterns in the bound peptide sequences.11 Conserved amino acid residues located at particular positions of the peptides act as peptide's anchoring residues in the peptide-binding groove.
HLA Binding (binding) of in groove
20) Confidence 0.12 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0 Pain Relevance 0

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