INT234076

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Context Info
Confidence 0.62
First Reported 2008
Last Reported 2008
Negated 2
Speculated 2
Reported most in Body
Documents 8
Total Number 12
Disease Relevance 1.85
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
neurons 3
GABAergic neurons 1
nervous system 1
Snap25 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 226 99.84 Very High Very High Very High
Neurotransmitter 89 97.44 Very High Very High Very High
Calcium channel 40 90.72 High High
Action potential 57 79.68 Quite High
Glutamate 16 75.84 Quite High
Pyramidal cell 58 58.08 Quite High
imagery 20 55.92 Quite High
Hippocampus 57 53.68 Quite High
Thalamus 20 52.64 Quite High
Catecholamine 17 51.00 Quite High
Disease Link Frequency Relevance Heat
Body Weight 20 98.48 Very High Very High Very High
Convulsion 65 98.28 Very High Very High Very High
Cognitive Disorder 38 97.56 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 25 95.84 Very High Very High Very High
Anxiety Disorder 20 84.96 Quite High
Targeted Disruption 55 84.24 Quite High
Stress 5 75.40 Quite High
Intellectual Impairment 5 64.20 Quite High
Schizophrenia 21 50.00 Quite Low
Tremor 10 42.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The neo-containing SNAP-25b mutants are most severely affected with frequent attacks debuting around PN12-13, whereas in neo-excised SNAP-25b deficient mutants seizure activity is rare prior to young adulthood.
Regulation (affected) of SNAP-25b associated with convulsion
1) Confidence 0.62 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.40 Pain Relevance 0
Developmental regulation of SNAP-25 in GABAergic neurons
Regulation (regulation) of SNAP-25 in GABAergic neurons associated with gabaergic
2) Confidence 0.62 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.09
The previous experiment examined the regulation of SNAP-25 isoforms within a fraction of cortical cells based globally on neurotransmitter phenotype.
Spec (examined) Regulation (regulation) of SNAP-25 associated with neurotransmitter
3) Confidence 0.62 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0.06 Pain Relevance 0.28
Unlike neo-containing homozygous SNAP-25b deficient mutants, the growth of neo-excised homozygous mutants between PN5 and 15 was not severely affected.
Neg (not) Regulation (affected) of SNAP-25b
4) Confidence 0.45 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.32 Pain Relevance 0
We suggest that the ancient duplication in the Snap25 gene followed by regulated alternative splicing between two similar but distinct exon 5 sequences is required for accurate synaptic function during development.
Regulation (followed) of Snap25
5) Confidence 0.45 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.45 Pain Relevance 0.03
To examine whether two SNAP-25 isoforms are differentially expressed in GABAergic neurons and therefore might play a role in tailoring the distinct properties of synaptic activity in these neurons, we utilized GAD67-GFP (?
Spec (whether) Regulation (two) of SNAP-25 in neurons associated with gabaergic
6) Confidence 0.45 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0.08 Pain Relevance 0.22
Moreover, the magnitude of the calcium response evoked in SNAP-25 null mutant neurons by exposure to high K+ depolarizing media was also equivalent to the responses measured in control Snap25+/- and Snap25+/+ neurons.
Regulation (control) of Snap25 in neurons
7) Confidence 0.39 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.20
These results suggest that tomosyn regulates the concentration of SNAP-25 in lipid raft microdomains.
Regulation (regulates) of SNAP-25
8) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.06
Three mouse lines, bred independently from each other for at least ten generations on C57BL/6NCrl (B6) mice, were termed “neo-containing” as the Tkneo gene inserted into the targeting vector was still present in the modified Snap25 gene.
Regulation (modified) of Snap25
9) Confidence 0.27 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.18 Pain Relevance 0
Our present findings using genetic elimination of SNAP-25b suggest that even small alterations in the regulation of the Snap25 gene, resulting in a disturbed balance between SNAP-25a and SNAP-25b, lead to nervous system dysfunction.



Regulation (regulation) of Snap25 in nervous system
10) Confidence 0.27 Published 2008 Journal PLoS Genetics Section Abstract Doc Link PMC2581893 Disease Relevance 0.36 Pain Relevance 0.03
Our results support the idea that regulation of SNAP-25 contributes to the developmental fine-tuning of a universal SNARE complex required for mature, stimulus-evoked synaptic transmission both in cultured neurons and by major populations of excitatory and inhibitory neurons.


Regulation (regulation) of SNAP-25 in neurons
11) Confidence 0.27 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.12
In our experiments, we did not find any changes in the steady-state levels of these exocytotic regulators, including SNARE proteins (SNAP25, syntaxin-1, and VAMP2), synaptotagamin-1, VGLUT1, munc18-1, dynamin-1, and complexin1/2 (Fig. 7).
Neg (not) Regulation (changes) of SNAP25
12) Confidence 0.19 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0 Pain Relevance 0

General Comments

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