INT234079

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.29
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Dtnbp1) endoplasmic reticulum (Dtnbp1) plasma membrane (Dtnbp1)
nucleus (Dtnbp1) cytoplasm (Dtnbp1)
Anatomy Link Frequency
neurons 1
spikes 1
LDCV 1
Dtnbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 15 94.68 High High
Glutamate 21 93.40 High High
addiction 33 89.00 High High
Nicotine 13 86.20 High High
opiate 16 85.24 High High
Pyramidal cell 21 81.84 Quite High
Action potential 3 76.60 Quite High
Hippocampus 48 64.96 Quite High
Dopamine 14 5.00 Very Low Very Low Very Low
Neurotransmitter 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Post-traumatic Stress Disorder 18 91.84 High High
Alcohol Addiction 9 89.00 High High
Nicotine Addiction 11 86.64 High High
Opiate Addiction 13 85.68 High High
Schizophrenia 102 82.72 Quite High
Anxiety Disorder 9 81.52 Quite High
Disease 10 76.56 Quite High
Congenital Anomalies 18 59.52 Quite High
Psychosis 19 5.00 Very Low Very Low Very Low
Bardet-biedl Syndrome 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We only found a slight and insignificant increase in the number of amperometric spikes (sdy, 14 ± 1 events per cell; sdy + dysbindin, 19 ± 3 events per cell; Fig. 2 D).
Positive_regulation (increase) of sdy in spikes
1) Confidence 0.61 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0 Pain Relevance 0
While a strong effect of DTNBP1 was observed in four clinically distinct phenotypes the results should be treated with caution as there is a considerable difference in the gender proportions between cases and controls, for example the PTSD cohort were all male while 41% of controls were women.
Positive_regulation (effect) of DTNBP1 associated with post-traumatic stress disorder
2) Confidence 0.50 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911395 Disease Relevance 1.18 Pain Relevance 0.63
Intracellular dialysis of purified full-length dysbindin rescues the sdy phenotype of LDCV secretion
Positive_regulation (rescues) of sdy in LDCV
3) Confidence 0.44 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0 Pain Relevance 0.03
However, a significant increase in the decay time constant (WT, 104 ± 19 ms; sdy, 190 ± 30 ms) was found in the sdy neurons.
Positive_regulation (increase) of sdy in neurons
4) Confidence 0.41 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0.11 Pain Relevance 0.19

General Comments

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