INT234083

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 1.41
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Stx1a) vesicle-mediated transport (Stx1a) plasma membrane (Stx1a)
protein binding, bridging (Stx1a) protein complex (Stx1a)
Anatomy Link Frequency
amacrine cells 3
Stx1a (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 14 99.88 Very High Very High Very High
gABA 20 98.44 Very High Very High Very High
Neurotransmitter 88 73.84 Quite High
GABAergic 21 69.92 Quite High
midbrain 6 53.84 Quite High
long-term potentiation 6 10.64 Low Low
Hippocampus 20 5.00 Very Low Very Low Very Low
anesthesia 11 5.00 Very Low Very Low Very Low
Pyramidal cell 11 5.00 Very Low Very Low Very Low
Action potential 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 288 100.00 Very High Very High Very High
Targeted Disruption 80 99.20 Very High Very High Very High
Aids-related Complex 4 82.60 Quite High
Retts Disease 68 57.80 Quite High
Schizophrenia 21 50.00 Quite Low
Disease 12 43.68 Quite Low
Cancer 9 23.52 Low Low
Congenital Anomalies 8 5.08 Very Low Very Low Very Low
Anxiety Disorder 16 5.00 Very Low Very Low Very Low
Autism 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
/y-EE mice have reduced expression of syntaxin 1A (Stx1a, 42.8±13.7%,), synaptotagmin (23.6±13.7%) and a trend for diminished expression of synaptophysin (46.5±16.8% p?
Gene_expression (expression) of syntaxin 1A
1) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.14 Pain Relevance 0.03
/y-EE mice have reduced expression of syntaxin 1A (Stx1a, 42.8±13.7%,), synaptotagmin (23.6±13.7%) and a trend for diminished expression of synaptophysin (46.5±16.8% p?
Gene_expression (expression) of Stx1a
2) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.14 Pain Relevance 0.03
In the GCL, 8.8% of HPC-1 immunoreactive displaced amacrine cells contain CFP and 9.6% of the total CFP-expressing cells in the GCL are HPC-1 immunoreactive displaced amacrine cells.
Gene_expression (contain) of HPC-1 in amacrine cells
3) Confidence 0.38 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.06 Pain Relevance 0.16
Many of the small and weakly CFP-fluorescent cells in the GCL also contained HPC-1 immunoreactivity (Figure 6F).
Gene_expression (contained) of HPC-1
4) Confidence 0.38 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.22 Pain Relevance 0
CFP expression was characterized using morphometric methods and immunohistochemistry with antibodies to neurofilament light (NF-L), neuronal nuclei (NeuN), POU-domain protein (Brn3a) and calretinin, which immunolabel ganglion cells, and syntaxin 1 (HPC-1), glutamate decarboxylase 67 (GAD67), GABA plasma membrane transporter-1 (GAT-1), and choline acetyltransferase (ChAT), which immunolabel amacrine cells.


Gene_expression (expression) of syntaxin 1 in amacrine cells associated with ganglion cysts, gaba and glutamate
5) Confidence 0.34 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2519030 Disease Relevance 0.43 Pain Relevance 0.10
For the expression of GST-fused syntaxin-1 (GST–syntaxin-1), GST-fused SNAP-25 (GST–SNAP-25), and GST-fused VAMP-2 (GST–VAMP-2), cDNAs encoding the cytoplasmic domain of syntaxin-1 (1–265 aa), full-length SNAP-25 (1–206 aa), and the cytoplasmic domain of VAMP-2 (1–94 aa) were subcloned into pGEX vectors (GE Healthcare).
Gene_expression (expression) of syntaxin-1
6) Confidence 0.31 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
CFP expression was characterized using morphometric methods and immunohistochemistry with antibodies to neurofilament light (NF-L), neuronal nuclei (NeuN), POU-domain protein (Brn3a) and calretinin, which immunolabel ganglion cells, and syntaxin 1 (HPC-1), glutamate decarboxylase 67 (GAD67), GABA plasma membrane transporter-1 (GAT-1), and choline acetyltransferase (ChAT), which immunolabel amacrine cells.


Gene_expression (expression) of HPC-1 in amacrine cells associated with ganglion cysts, gaba and glutamate
7) Confidence 0.30 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2519030 Disease Relevance 0.43 Pain Relevance 0.10
GST–syntaxin-1, GST–SNAP-25, and GS–VAMP-2 were expressed in E. coli and purified with glutathione–Sepharose 4B (GE Healthcare) in accordance with the manufacturer's manual.
Gene_expression (expressed) of syntaxin-1
8) Confidence 0.27 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
First, we examined the effect of tomosyn deficiency on the expression levels of SNARE proteins, including syntaxin-1, SNAP-25, VAMP-2, and complexin.
Gene_expression (expression) of syntaxin-1
9) Confidence 0.24 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
For the expression of GST-fused syntaxin-1 (GST–syntaxin-1), GST-fused SNAP-25 (GST–SNAP-25), and GST-fused VAMP-2 (GST–VAMP-2), cDNAs encoding the cytoplasmic domain of syntaxin-1 (1–265 aa), full-length SNAP-25 (1–206 aa), and the cytoplasmic domain of VAMP-2 (1–94 aa) were subcloned into pGEX vectors (GE Healthcare).
Gene_expression (expression) of syntaxin-1
10) Confidence 0.21 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
In our experiments, we did not find any changes in the steady-state levels of these exocytotic regulators, including SNARE proteins (SNAP25, syntaxin-1, and VAMP2), synaptotagamin-1, VGLUT1, munc18-1, dynamin-1, and complexin1/2 (Fig. 7).
Gene_expression (/) of syntaxin-1
11) Confidence 0.05 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0 Pain Relevance 0

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