INT234084

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.32
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Napb) vesicle-mediated transport (Napb)
Anatomy Link Frequency
vesicles 4
Napb (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 204 98.74 Very High Very High Very High
gABA 30 97.08 Very High Very High Very High
antidepressant 78 82.88 Quite High
antagonist 18 70.48 Quite High
imagery 3 50.16 Quite High
Pyramidal cell 37 23.92 Low Low
Desipramine 12 14.44 Low Low
fluoxetine 9 11.76 Low Low
Glutamate receptor 6 8.92 Low Low
Neurotransmitter 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 327 99.62 Very High Very High Very High
Urological Neuroanatomy 18 52.88 Quite High
Suicidal Behaviour 3 51.44 Quite High
Schizophrenia 24 50.80 Quite High
Disease 14 36.48 Quite Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Shock 9 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Bardet-biedl Syndrome 4 5.00 Very Low Very Low Very Low
Psychosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been proposed that snapin stabilizes the release-ready vesicles by enhancing the interaction of the SNARE proteins with synaptotagmin during the priming process (Tian et al., 2005).
Positive_regulation (enhancing) of SNARE Binding (interaction) of in vesicles
1) Confidence 0.12 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0 Pain Relevance 0
The increase of glutamate release induced in P/FC by footshock stress is accompanied by accumulation of SNARE complexes in the presynaptic membrane
Positive_regulation (accumulation) of SNARE Binding (complexes) of associated with stress and glutamate
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.79 Pain Relevance 0.43
Previous evidence has shown that the number of SNARE complexes can be increased by chemical treatment of synaptosomes, suggesting a correlation between the accumulation of complexes and the number of vesicles available for release [25].
Positive_regulation (increased) of SNARE Binding (complexes) of in vesicles
3) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.52 Pain Relevance 0.18
Measurement of SNARE complex in isolated presynaptic membranes
Positive_regulation (Measurement) of SNARE Binding (complex) of
4) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0 Pain Relevance 0.20

General Comments

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