INT234087

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.07
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Dtnbp1) endoplasmic reticulum (Dtnbp1) plasma membrane (Dtnbp1)
nucleus (Dtnbp1) cytoplasm (Dtnbp1)
Anatomy Link Frequency
cortex 5
synapses 2
hippocampus 1
Dtnbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 48 100.00 Very High Very High Very High
Dopamine 14 99.96 Very High Very High Very High
cerebral cortex 1 97.36 Very High Very High Very High
Glutamate 21 97.28 Very High Very High Very High
agonist 1 89.24 High High
Glutamate receptor 1 88.92 High High
Pyramidal cell 21 62.68 Quite High
Action potential 3 57.44 Quite High
nMDA receptor 1 47.92 Quite Low
GABAergic 3 45.16 Quite Low
Disease Link Frequency Relevance Heat
Schizophrenia 102 99.72 Very High Very High Very High
Congenital Anomalies 18 95.44 Very High Very High Very High
Psychosis 19 84.04 Quite High
Cognitive Disorder 10 75.52 Quite High
Disease 10 47.36 Quite Low
Manic Depressive Disorder 3 31.44 Quite Low
Post-traumatic Stress Disorder 18 5.00 Very Low Very Low Very Low
Opiate Addiction 13 5.00 Very Low Very Low Very Low
Bardet-biedl Syndrome 12 5.00 Very Low Very Low Very Low
Nicotine Addiction 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduced DTNBP1 mRNA and protein expression has been found in the hippocampal formation and dorsolateral prefrontal cortex of schizophrenia patients [11-13].
Negative_regulation (Reduced) of Gene_expression (expression) of DTNBP1 in cortex associated with schizophrenia
1) Confidence 0.42 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911395 Disease Relevance 0.84 Pain Relevance 0.22
More recently, it has been shown that the sandy (sdy) mouse, which harbors a large deletion within the dysbindin gene and has no dysbindin protein expression (Li et al., 2003), has reduced dopamine levels in the cortex and hippocampus (Murotani et al., 2007).
Negative_regulation (reduced) of Neg (no) Gene_expression (expression) of sdy in cortex associated with dopamine and hippocampus
2) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0.49 Pain Relevance 0.28
Morphological changes in asymmetrical synapses of sdy hippocampus
Negative_regulation (synapses) of Gene_expression (hippocampus) of sdy in synapses associated with hippocampus
3) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0.25 Pain Relevance 0.27
More recently, it has been shown that the sandy (sdy) mouse, which harbors a large deletion within the dysbindin gene and has no dysbindin protein expression (Li et al., 2003), has reduced dopamine levels in the cortex and hippocampus (Murotani et al., 2007).
Negative_regulation (reduced) of in hippocampus Neg (no) Gene_expression (expression) of sdy in cortex associated with dopamine and hippocampus
4) Confidence 0.13 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0.49 Pain Relevance 0.28

General Comments

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