INT234090

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.09
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Dtnbp1) endoplasmic reticulum (Dtnbp1) plasma membrane (Dtnbp1)
nucleus (Dtnbp1) cytoplasm (Dtnbp1)
Anatomy Link Frequency
neurons 2
chromaffin cells 2
synapses 2
cortex 2
hippocampus 2
Dtnbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 160 100.00 Very High Very High Very High
Dopamine 28 98.72 Very High Very High Very High
Glutamate 63 98.40 Very High Very High Very High
cerebral cortex 1 97.04 Very High Very High Very High
Neurotransmitter 40 92.64 High High
agonist 1 88.92 High High
Glutamate receptor 1 88.60 High High
Pyramidal cell 70 85.20 High High
Action potential 10 79.96 Quite High
nMDA receptor 1 47.92 Quite Low
Disease Link Frequency Relevance Heat
Schizophrenia 249 99.40 Very High Very High Very High
Congenital Anomalies 60 98.76 Very High Very High Very High
Psychosis 47 84.04 Quite High
Cognitive Disorder 31 75.52 Quite High
Syndrome 21 60.08 Quite High
Disease 24 44.88 Quite Low
Manic Depressive Disorder 3 31.44 Quite Low
Bardet-biedl Syndrome 40 5.00 Very Low Very Low Very Low
Depression 30 5.00 Very Low Very Low Very Low
Post-traumatic Stress Disorder 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduced DTNBP1 mRNA and protein expression has been found in the hippocampal formation and dorsolateral prefrontal cortex of schizophrenia patients [11-13].
Gene_expression (expression) of DTNBP1 in cortex associated with schizophrenia
1) Confidence 0.67 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911395 Disease Relevance 0.84 Pain Relevance 0.22
Our previous results have demonstrated that the sandy (sdy) mouse harbors a spontaneously occurring deletion in the DTNBP1 gene and expresses no dysbindin protein (Li, W., Q.
Neg (no) Gene_expression (expresses) of DTNBP1
2) Confidence 0.60 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2396815 Disease Relevance 0.25 Pain Relevance 0
These abnormalities might cause an abnormal efficacy of synaptic transmission in sdy synapses.
Gene_expression (synapses) of sdy in synapses associated with congenital anomalies
3) Confidence 0.59 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0.64 Pain Relevance 0.09
Smaller RRP size in sdy chromaffin cells and hippocampus
Gene_expression (chromaffin cells) of sdy in hippocampus associated with hippocampus
4) Confidence 0.59 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0 Pain Relevance 0.18
Morphological changes in asymmetrical synapses of sdy hippocampus
Gene_expression (hippocampus) of sdy in synapses associated with hippocampus
5) Confidence 0.59 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0.25 Pain Relevance 0.27
More recently, it has been shown that the sandy (sdy) mouse, which harbors a large deletion within the dysbindin gene and has no dysbindin protein expression (Li et al., 2003), has reduced dopamine levels in the cortex and hippocampus (Murotani et al., 2007).
Neg (no) Gene_expression (expression) of sdy in cortex associated with dopamine and hippocampus
6) Confidence 0.59 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0.49 Pain Relevance 0.27
Morphological changes in LDCVs of sdy chromaffin cells
Gene_expression (chromaffin cells) of sdy in chromaffin cells
7) Confidence 0.59 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0 Pain Relevance 0
The RT of EPSCs (WT, 17 ± 3 ms; sdy, 24 ± 3 ms) was slightly higher in sdy neurons, but the change was statistically insignificant.
Gene_expression (neurons) of sdy in neurons
8) Confidence 0.59 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0 Pain Relevance 0.19
However, a significant increase in the decay time constant (WT, 104 ± 19 ms; sdy, 190 ± 30 ms) was found in the sdy neurons.
Gene_expression (neurons) of sdy in neurons
9) Confidence 0.59 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0.12 Pain Relevance 0.19
Smaller RRP size in sdy chromaffin cells and hippocampus
Gene_expression (chromaffin cells) of sdy in chromaffin cells associated with hippocampus
10) Confidence 0.20 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0 Pain Relevance 0.18
More recently, it has been shown that the sandy (sdy) mouse, which harbors a large deletion within the dysbindin gene and has no dysbindin protein expression (Li et al., 2003), has reduced dopamine levels in the cortex and hippocampus (Murotani et al., 2007).
Neg (no) Gene_expression (expression) of sdy in hippocampus associated with dopamine and hippocampus
11) Confidence 0.20 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0.49 Pain Relevance 0.27

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