INT234092

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.17
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

vesicle-mediated transport (Vamp2) plasma membrane (Vamp2) protein complex assembly (Vamp2)
Anatomy Link Frequency
brain 1
Vamp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 28 96.16 Very High Very High Very High
long-term potentiation 26 17.84 Low Low
Pyramidal cell 11 5.00 Very Low Very Low Very Low
nMDA receptor 9 5.00 Very Low Very Low Very Low
Glutamate 8 5.00 Very Low Very Low Very Low
Neurotransmitter 7 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 12 89.12 High High
Schizophrenia 21 50.00 Quite Low
Cognitive Disorder 11 5.00 Very Low Very Low Very Low
Bardet-biedl Syndrome 4 5.00 Very Low Very Low Very Low
Psychosis 4 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Convulsion 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our experiments, we did not find any changes in the steady-state levels of these exocytotic regulators, including SNARE proteins (SNAP25, syntaxin-1, and VAMP2), synaptotagamin-1, VGLUT1, munc18-1, dynamin-1, and complexin1/2 (Fig. 7).
Neg (not) Regulation (changes) of VAMP2
1) Confidence 0.20 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0 Pain Relevance 0
The absence of Neto1 had no effect on the overall abundance of NR1, NR2A, NR2B, PSD-95, GluR2, VAMP2, or GABAAR1 proteins (Figure 6L) in whole brain extracts, or of NR1, NR2A, NR2B, or PSD-95 in crude synaptosomes (Figure 6M).
Neg (no) Regulation (effect) of VAMP2 in brain
2) Confidence 0.18 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.17 Pain Relevance 0.05

General Comments

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