INT234116

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.78
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (MID1) ligase activity (MID1) cytoplasm (MID1)
Anatomy Link Frequency
Tendon 3
plasma 1
blood 1
brain 1
MID1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 12 99.98 Very High Very High Very High
Neuritis 42 96.48 Very High Very High Very High
Inflammation 36 91.12 High High
Inflammatory mediators 1 86.00 High High
Pain 62 82.00 Quite High
substance P 7 81.36 Quite High
b2 receptor 7 77.36 Quite High
Central nervous system 35 76.92 Quite High
antagonist 17 75.52 Quite High
Multiple sclerosis 24 48.48 Quite Low
Disease Link Frequency Relevance Heat
Injury 24 97.28 Very High Very High Very High
Neuromyelitis Optica 72 96.94 Very High Very High Very High
Targeted Disruption 3 96.80 Very High Very High Very High
Increased Venous Pressure Under Development 19 96.52 Very High Very High Very High
Optic Neuritis 42 96.48 Very High Very High Very High
Pressure And Volume Under Development 17 94.12 High High
INFLAMMATION 40 91.12 High High
Pain 50 82.00 Quite High
Disease 58 81.76 Quite High
Brain Injury 27 81.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BK increases the permeability of the BBB to small solutes and increases blood pressure in the microcirculation due to arterial vasodilatation and venous constriction [3].
Positive_regulation (increases) of BBB in blood associated with increased venous pressure under development and bradykinin
1) Confidence 0.03 Published 2009 Journal Trials Section Body Doc Link PMC2794266 Disease Relevance 1.13 Pain Relevance 0.48
Figure 4 shows an example of histological appearance of brain sections from an animal where BBB disruption was not induced; this was also previously quantified by contrast-enhanced MRI and post-mortem histological evaluation of Evan Blue (Figure 2).
Neg (not) Positive_regulation (induced) of BBB in brain
2) Confidence 0.03 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2842276 Disease Relevance 0 Pain Relevance 0
Increased BBB permeability can be either a consequence of the pathology or a precipitating event [7, 8].
Positive_regulation (Increased) of BBB
3) Confidence 0.01 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 0.67 Pain Relevance 0.20
A number of recent in vitro and in vivo studies revealed that IgG from patients with NMO initiates endocytosis of AQP4, a process which alters the polarized expression pattern of AQP4 on the plasma membrane and, as a functional consequence, increases BBB permeability in vitro [35-37].
Positive_regulation (increases) of BBB in plasma associated with neuromyelitis optica
4) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2945323 Disease Relevance 0.76 Pain Relevance 0.21
Finally, AQP4-Ab itself could induce BBB damage.
Positive_regulation (induce) of BBB
5) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2945323 Disease Relevance 0.59 Pain Relevance 0.25
In a recent animal study, induction of BBB damage by pretreatment with complete Freund's adjuvans was in fact sufficient to cause NMO-like lesions following passive transfer of AQP4-Ab positive sera [28].
Positive_regulation (induction) of BBB associated with neuromyelitis optica
6) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2945323 Disease Relevance 0.16 Pain Relevance 0
Tendon oxygen saturation increased significantly in group A at insertion (70 ± 11 vs.75 ± 7%, p = 0.001) and distal mid-portion (68 ± 12 vs.73 ± 9%, p = 0.006), which was significantly increased vs. group B distal mid-portion (69 ± 11 vs.68 ± 15%, p = 0.041 vs.A).
Positive_regulation (increased) of mid-portion in Tendon
7) Confidence 0.00 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2397381 Disease Relevance 0.16 Pain Relevance 0.16
Tendon oxygen saturation increased significantly in group A at insertion (70 ± 11 vs.75 ± 7%, p = 0.001) and distal mid-portion (68 ± 12 vs.73 ± 9%, p = 0.006), which was significantly increased vs. group B distal mid-portion (69 ± 11 vs.68 ± 15%, p = 0.041 vs.A).
Positive_regulation (increased) of mid-portion in Tendon
8) Confidence 0.00 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2397381 Disease Relevance 0.15 Pain Relevance 0.15
Tendon oxygen saturation increased significantly in group A at insertion (70 ± 11 vs.75 ± 7%, p = 0.001) and distal mid-portion (68 ± 12 vs.73 ± 9%, p = 0.006), which was significantly increased vs. group B distal mid-portion (69 ± 11 vs.68 ± 15%, p = 0.041 vs.A).
Positive_regulation (increased) of mid-portion in Tendon
9) Confidence 0.00 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2397381 Disease Relevance 0.16 Pain Relevance 0.16

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