INT234159

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.61
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Olig2) nucleus (Olig2) DNA binding (Olig2)
cytoplasm (Olig2)
Anatomy Link Frequency
oligodendrocytes 2
Olig2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 10 80.00 Quite High
Multiple sclerosis 2 63.44 Quite High
Central nervous system 82 58.00 Quite High
Hippocampus 38 12.72 Low Low
Inflammation 28 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
cocaine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 16 90.56 High High
Death 20 83.44 Quite High
Ataxia 2 76.32 Quite High
Apoptosis 24 71.60 Quite High
Cancer 26 64.96 Quite High
Demyelinating Disease 6 63.44 Quite High
Colon Cancer 2 60.76 Quite High
Leukoencephalopathies 8 53.12 Quite High
Congenital Anomalies 2 48.96 Quite Low
Drug Induced Neurotoxicity 4 48.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings of aberrant regulation of Olig2 expression, with the presence of many Olig2-negative oligodendrocytes at 56 days after treatment, provide the first indication that chemotherapy alters the normal expression of important transcriptional regulators in oligodendrocytes.
Regulation (regulation) of Gene_expression (expression) of Olig2 in oligodendrocytes
1) Confidence 0.56 Published 2008 Journal J Biol Section Body Doc Link PMC2397490 Disease Relevance 0.37 Pain Relevance 0.07
At earlier time points, there were no increases greater than 0.1 ms in these inter-peak latencies in either the control or the treated groups.

5-FU treatment causes delayed changes in expression of Olig2 and loss of myelin integrity

Regulation (changes) of Gene_expression (expression) of Olig2
2) Confidence 0.41 Published 2008 Journal J Biol Section Body Doc Link PMC2397490 Disease Relevance 0.25 Pain Relevance 0.03

General Comments

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