INT234186

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.48
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (BRCA2) chromosome organization (BRCA2) nucleolus (BRCA2)
nucleus (BRCA2) cell cycle (BRCA2) DNA binding (BRCA2)
BRCA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 3 65.76 Quite High
imagery 17 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 78 97.56 Very High Very High Very High
Genomic Instability 1 97.40 Very High Very High Very High
Chromosomal Instability 1 95.56 Very High Very High Very High
Death 4 94.24 High High
Cancer 125 94.08 High High
Breast Cancer 167 90.44 High High
Fanconi Anemia 2 72.88 Quite High
Neutropenia 2 68.04 Quite High
Pain 3 65.76 Quite High
Ovarian Cancer 50 51.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increasing knowledge of BRCA1 and BRCA2 acts as an exemplar resulting in improved patient care.
Localization (knowledge) of BRCA2
1) Confidence 0.69 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397525 Disease Relevance 0.68 Pain Relevance 0
If somatic mutations or epigenetic silencing leads to the absence of either BRCA1 or BRCA2, alternative DNA repair pathways such as nonhomologous end joining are employed; this subsequently results in chromosomal instability and cell death [54].
Neg (absence) Localization (absence) of BRCA2 associated with chromosomal instability and death
2) Confidence 0.25 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2814233 Disease Relevance 0.80 Pain Relevance 0.07

General Comments

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