INT234193

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.50
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tpt1) extracellular space (Tpt1) transcription factor binding (Tpt1)
cytoplasm (Tpt1)
Anatomy Link Frequency
myoblasts 1
Tpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Immobilon 1 93.92 High High
Potency 7 86.24 High High
cytokine 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 78 91.20 High High
Cancer 201 88.88 High High
Infection 25 81.28 Quite High
Disease 15 79.20 Quite High
Apoptosis 59 72.16 Quite High
Breast Cancer 72 50.00 Quite Low
Myotonic Dystrophy 22 50.00 Quite Low
Targeted Disruption 26 49.84 Quite Low
Death 9 38.96 Quite Low
Shock 16 29.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Membranes were sequentially blocked in 5% dry milk for 1 hour at RT and then incubated with anti-p53, P21 and P16 antibodies at 1?
P21 Binding (antibodies) of
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.10 Pain Relevance 0.05
In order to explore the underlying molecular mechanism of CIAPIN1 affecting the cell cycle progression, we detected the expression of cell cycle-related molecules in AdSiCIAPIN1-infected SMMC-7721 cells, such as cyclinD1, p27, cdk2, cdk4 and p21 by western blot and found cdk2, cdk4 and p21 were not affected (data not show), except CyclyinD1 was downregulated and P27 was upregulated (Figure3F).
p21 Binding (cyclinD1) of
2) Confidence 0.08 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.02 Pain Relevance 0
These changes of CUGBP1 phosphorylation in DM1 myogenesis lead to the increase of cyclin D1 in DM1 myoblasts and to the reduction p21 in DM1 myotubes [68] (Fig. 7).
p21 Binding (lead) of in myoblasts
3) Confidence 0.05 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.08 Pain Relevance 0
co-immunoprecipitating with p23.
p23 Binding (immunoprecipitating) of
4) Confidence 0.05 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.09 Pain Relevance 0.04
To asses whether systemic administration of NVP-AUY922 could affect the association between p23 and HSP90 observed in vitro, HSP90?
p23 Binding (association) of
5) Confidence 0.05 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.21 Pain Relevance 0

General Comments

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