INT234207

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.84
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90AA1) small molecule metabolic process (HSP90AA1) intracellular (HSP90AA1)
response to stress (HSP90AA1) cytoplasm (HSP90AA1) cytosol (HSP90AA1)
HSP90AA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 3 93.44 High High
addiction 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 31 90.84 High High
Cancer 62 85.60 High High
Stress 20 74.76 Quite High
Breast Cancer 36 50.00 Quite Low
Apoptosis 13 5.00 Very Low Very Low Very Low
Death 9 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Colon Cancer 3 5.00 Very Low Very Low Very Low
Skin Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NVP-AUY922 appears to be more potent than 17-AAG at inhibiting the HSP90-p23 interaction.
Negative_regulation (inhibiting) of HSP90-p23 Binding (interaction) of
1) Confidence 0.26 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.09 Pain Relevance 0.05
HNE treatment has been shown in vitro to adduct specific amino acid residues on both Hsp70 and Hsp90, which correlates with their reduced ability to bind and properly fold client proteins.28,29 We performed coimmunoprecipitation experiments with myc-tagged Hsp70, demonstrating that its association with HSF1 is disrupted by HNE treatment.
Negative_regulation (reduced) of Hsp90 Binding (bind) of
2) Confidence 0.26 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.75 Pain Relevance 0

General Comments

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