INT234208

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90AA1) small molecule metabolic process (HSP90AA1) intracellular (HSP90AA1)
response to stress (HSP90AA1) cytoplasm (HSP90AA1) cytosol (HSP90AA1)
HSP90AA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 55.56 Quite High
Potency 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 53 89.80 High High
Breast Cancer 36 86.16 High High
Hematologic Neoplasms 2 29.72 Quite Low
Solid Tumor 2 28.48 Quite Low
Shock 8 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Colon Cancer 2 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HSP90 inhibitors affect AKT activity indirectly through depletion of upstream signaling molecules (for example, ERBB family members) and directly by preventing HSP90-dependent conformational stability of AKT [17,21,22].
Negative_regulation (preventing) of Localization (stability) of HSP90-dependent
1) Confidence 0.26 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.59 Pain Relevance 0.03

General Comments

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