INT234211

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.13
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90AA1) small molecule metabolic process (HSP90AA1) intracellular (HSP90AA1)
response to stress (HSP90AA1) cytoplasm (HSP90AA1) cytosol (HSP90AA1)
Anatomy Link Frequency
BT-474 2
HSP90AA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 6 71.92 Quite High
antagonist 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 75 98.96 Very High Very High Very High
Cancer 185 97.98 Very High Very High Very High
Colon Cancer 55 97.80 Very High Very High Very High
Shock 24 97.76 Very High Very High Very High
Apoptosis 10 87.08 High High
Stress 5 63.92 Quite High
Glioblastoma 2 48.96 Quite Low
Skin Cancer 3 48.24 Quite Low
Malignant Neoplastic Disease 4 44.72 Quite Low
Targeted Disruption 3 20.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Destabilization of the HSP90-p23 interaction in tumor cells and the subsequent measurement using immunoprecipitation therefore can be used to monitor the effect of HSP90 inhibitors on the HSP90 catalytic cycle (Figure 1b).
Regulation (effect) of Negative_regulation (inhibitors) of HSP90 associated with cancer
1) Confidence 0.27 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.10 Pain Relevance 0.04
BT-474 and SKBr3 have often been used to examine the effects of HSP90 inhibitors in high ERBB2 expressing breast cancer cell lines.
Spec (examine) Regulation (effects) of Spec (examine) Negative_regulation (inhibitors) of HSP90 in BT-474 associated with breast cancer
2) Confidence 0.27 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.50 Pain Relevance 0.03
Importantly, such protein up-regulation in response to Hsp90 inhibition has thus far only been reported for certain other heat-shock proteins such as HSF1 and Hsp70.
Regulation (response) of Negative_regulation (inhibition) of Hsp90 associated with shock
3) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.53 Pain Relevance 0

General Comments

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