INT234212

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.36
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90AA1) small molecule metabolic process (HSP90AA1) intracellular (HSP90AA1)
response to stress (HSP90AA1) cytoplasm (HSP90AA1) cytosol (HSP90AA1)
HSP90AA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
qutenza 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 137 99.84 Very High Very High Very High
Stress 16 98.42 Very High Very High Very High
Shock 23 94.00 High High
Malignant Neoplastic Disease 5 90.32 High High
Breast Cancer 39 87.32 High High
Colon Cancer 53 80.20 Quite High
Myeloid Leukemia 12 50.00 Quite Low
Chronic Myeloid Leukemia 9 50.00 Quite Low
Apoptosis 16 30.08 Quite Low
Metastasis 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hsp90, one of the most studied molecular chaperons, is overexpressed in tumor cells and is essential for the stability and function of a wide range of oncogenic client proteins [4].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Hsp90 associated with cancer
1) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.80 Pain Relevance 0
NVP-AUY922 induces HSP90-p23 dissociation and client protein depletion in a concentration- and time-dependent manner
Positive_regulation (induces) of Gene_expression (dissociation) of HSP90-p23
2) Confidence 0.30 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.46 Pain Relevance 0
While proposing the role of Akt in downregulating Hsp70 by Resveratrol in K562 cells we contradicted the observation of induction of stress response by 17AAG, a drug that is also known to lower Akt levels (Fig. 4A) by virtue of its action on Hsp90. 17AAG was found to reduce ser473 phosphorylation of Akt and ser9 phosphorylation of Gsk3?
Positive_regulation (virtue) of Gene_expression (action) of Hsp90 associated with stress
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.10 Pain Relevance 0

General Comments

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