INT234214

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (HSP90AA1, Tpt1) nucleoplasm (Tpt1) unfolded protein binding (HSP90AA1)
small molecule metabolic process (HSP90AA1) intracellular (HSP90AA1) response to stress (HSP90AA1)
HSP90AA1 (Homo sapiens)
Tpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 9 33.60 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 159 72.24 Quite High
Breast Cancer 108 55.12 Quite High
Shock 24 5.00 Very Low Very Low Very Low
Body Weight 18 5.00 Very Low Very Low Very Low
Solid Tumor 6 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Hematologic Neoplasms 6 5.00 Very Low Very Low Very Low
Colon Cancer 6 5.00 Very Low Very Low Very Low
Hyperplasia 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HSP90-p23 interaction requires ATP binding but not ATP hydrolysis in biochemical assays, and p23 specifically recognizes HSP90-ATP complexes but not HSP90 alone [28].
HSP90 Binding (recognizes) of p23
1) Confidence 0.04 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.12 Pain Relevance 0
HSP90-p23 interaction requires ATP binding but not ATP hydrolysis in biochemical assays, and p23 specifically recognizes HSP90-ATP complexes but not HSP90 alone [28].
HSP90 Binding (recognizes) of p23
2) Confidence 0.04 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.13 Pain Relevance 0
HSP90 recruits various cochaperones at different points in its catalytic cycle, and the association of HSP90 with p23 is essential for HSP90 activity and client protein stability.
HSP90 Binding (association) of p23
3) Confidence 0.04 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.17 Pain Relevance 0

General Comments

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