INT234249

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.21
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PSEN1) Golgi apparatus (PSEN1) endoplasmic reticulum (PSEN1)
embryo development (PSEN1) peptidase activity (PSEN1) cell death (PSEN1)
Anatomy Link Frequency
fibroblasts 1
PSEN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 75 99.30 Very High Very High Very High
cINOD 33 87.40 High High
Inflammation 20 5.00 Very Low Very Low Very Low
aspirin 12 5.00 Very Low Very Low Very Low
Potency 8 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
b2 receptor 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 233 100.00 Very High Very High Very High
INFLAMMATION 21 87.16 High High
Down Syndrome 16 70.80 Quite High
Stress 102 69.84 Quite High
Alzheimer's Dementia 23 60.80 Quite High
Apoptosis 24 5.00 Very Low Very Low Very Low
Toxicity 17 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 5.00 Very Low Very Low Very Low
Neuroblastoma 8 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased BK responsiveness of ERK activity is specific to PS-1 FAD mutations in AD fibroblasts
Regulation (specific) of PS-1 in fibroblasts associated with disease and bradykinin
1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.25 Pain Relevance 0.34
42 was only observed for half of the mutations [23,24], further strengthening the notion that the mechanistic effects of PS1 mutations on the onset of FAD are complex.
Regulation (effects) of FAD associated with disease
2) Confidence 0.37 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.41 Pain Relevance 0
42 was only observed for half of the mutations [23,24], further strengthening the notion that the mechanistic effects of PS1 mutations on the onset of FAD are complex.
Regulation (effects) of PS1 associated with disease
3) Confidence 0.37 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.41 Pain Relevance 0
Consistently, PS1-D257TG and PS1-D385TG mutants were also affected differently by ?
Regulation (affected) of PS1-D385TG
4) Confidence 0.22 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0
Consistently, PS1-D257TG and PS1-D385TG mutants were also affected differently by ?
Regulation (affected) of PS1-D257TG
5) Confidence 0.22 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0
Figure 5A shows inhibition of MCMJR1 activity against Gurken-TMD by 31C, a transition state analog inhibitor known to target presenilin [29] and SPP [22].
Regulation (target) of presenilin
6) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947513 Disease Relevance 0.15 Pain Relevance 0.09

General Comments

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