INT234255

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.98
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
neurons 2
IMR-32 1
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 21.36 Low Low
Inflammation 4 20.00 Low Low
member 8 2 15.24 Low Low
Central nervous system 40 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
interneuron 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 14 100.00 Very High Very High Very High
Neuroblastoma 2 99.70 Very High Very High Very High
Aging 156 78.76 Quite High
Apoptosis 16 72.00 Quite High
Disease 31 38.68 Quite Low
Death 2 29.96 Quite Low
Stress 4 28.84 Quite Low
Necrosis 4 22.16 Low Low
Cancer 4 21.80 Low Low
INFLAMMATION 4 20.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transient transfection of these PS1 mutant constructs into the human IMR-32 neuroblastoma cells or a mouse neuroblastoma cell line N2A-APP, which expresses human Swedish APP as previously described [42,43], also produced similar patterns of A?
Transcription (described) of APP in IMR-32 associated with neuroblastoma
1) Confidence 0.49 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.20 Pain Relevance 0
As shown in Figure 8A the expression level of both presenilin and amyloid precursor protein (APP) mRNAs was higher in older animals (similar changes were also found for MCC neurons).
Transcription (level) of APP in neurons associated with alzheimer's dementia
2) Confidence 0.30 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2910937 Disease Relevance 0.39 Pain Relevance 0
As shown in Figure 8A the expression level of both presenilin and amyloid precursor protein (APP) mRNAs was higher in older animals (similar changes were also found for MCC neurons).
Transcription (expression) of APP in neurons associated with alzheimer's dementia
3) Confidence 0.30 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2910937 Disease Relevance 0.39 Pain Relevance 0

General Comments

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