INT234263

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.90
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (ELF3) nucleolus (ELF3) nucleus (ELF3)
extracellular matrix organization (ELF3) embryo development (ELF3) cytoplasm (ELF3)
Anatomy Link Frequency
endothelium 1
cardiac valve 1
ELF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 13 87.44 High High
Pain 45 46.16 Quite Low
Central nervous system 8 30.80 Quite Low
imagery 31 5.00 Very Low Very Low Very Low
Codeine 16 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 6 5.00 Very Low Very Low Very Low
Neuropathic pain 5 5.00 Very Low Very Low Very Low
medulla 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatomegaly 5 99.78 Very High Very High Very High
Disease Progression 9 99.70 Very High Very High Very High
Valvular Heart Disease Other Than Mitral Valve Prolapse 2 99.56 Very High Very High Very High
Splenomegaly 2 99.38 Very High Very High Very High
Cough 52 99.24 Very High Very High Very High
Disease 110 98.60 Very High Very High Very High
Fabry Disease 234 97.68 Very High Very High Very High
Mucopolysaccharidosis I 28 96.74 Very High Very High Very High
Gauchers Disease 61 96.64 Very High Very High Very High
Proteinuria 106 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ERT was shown to reduce GL-3 accumulation in dermal endothelium in children with Fabry disease (Wraith et al 2008).
Negative_regulation (reduce) of ERT in endothelium associated with fabry disease
1) Confidence 0.39 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 0.56 Pain Relevance 0.04
A recent case report of two siblings with Hurler-Scheie syndrome who began ERT at 5 months and 5 years of age, respectively, suggests that many MPS I disease manifestations, including cardiac valve disease, can be prevented if ERT is begun at an early age, but only partially reversed or stabilized if begun at a later age (Gabrielli et al. 2009).
Negative_regulation (reversed) of ERT in cardiac valve associated with valvular heart disease other than mitral valve prolapse, mucopolysaccharidosis i and disease
2) Confidence 0.33 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2903709 Disease Relevance 1.04 Pain Relevance 0
The number of patients with splenomegaly and/or hepatomegaly tended to decline during ERT, and most bone lesions other than BE tended to regress (Table 2).
Negative_regulation (decline) of ERT associated with splenomegaly and hepatomegaly
3) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.28 Pain Relevance 0
Their concentrations rise with disease progression and generally decrease during ERT [17].
Negative_regulation (decrease) of ERT associated with disease progression
4) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 1.12 Pain Relevance 0
From urinary Gb3 studies, it appears that persistence of antibodies impairs ERT at a dose of 0.2 mg/kg EOW.
Negative_regulation (impairs) of ERT
5) Confidence 0.18 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3009617 Disease Relevance 0.22 Pain Relevance 0
However, the cough number was typically higher than the number of ERt (Fig. 1).
Negative_regulation (number) of ERt associated with cough
6) Confidence 0.16 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 0.68 Pain Relevance 0

General Comments

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