INT234289

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 5.79
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Swd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 6 97.40 Very High Very High Very High
withdrawal 6 84.36 Quite High
Glutamate receptor 4 77.76 Quite High
Central nervous system 24 72.44 Quite High
drug abuse 6 66.36 Quite High
noradrenaline 6 57.76 Quite High
psychological dependence 6 49.16 Quite Low
Neurobehavioral 6 45.88 Quite Low
Intracerebroventricular 6 45.24 Quite Low
Thalamus 13 43.48 Quite Low
Disease Link Frequency Relevance Heat
Apnoea 264 100.00 Very High Very High Very High
Hypersomnia 522 99.98 Very High Very High Very High
Ulcers 6 97.84 Very High Very High Very High
Depression 6 97.40 Very High Very High Very High
Sleep Disorders 318 95.40 Very High Very High Very High
Obesity 6 87.32 High High
Exanthema 30 86.08 High High
Fatigue 6 84.88 Quite High
Affective Disorder 6 74.80 Quite High
Hallucination 12 71.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More than 3500 patients have been evaluated for safety in clinical studies of modafinil for treatment of excessive sleepiness associated with OSA, SWD, and narcolepsy (Schwartz 2005; PROVIGILĀ® 2007).
SWD Binding (associated) of associated with apnoea and hypersomnia
1) Confidence 0.03 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761173 Disease Relevance 1.23 Pain Relevance 0.04
The R-enantiomer, also known as armodafinil, has recently been approved to treat excessive sleepiness associated with OSA, SWD, and narcolepsy (NUVIGILĀ® 2007), but is not yet commercially available.
SWD Binding (associated) of associated with apnoea and hypersomnia
2) Confidence 0.03 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761173 Disease Relevance 0.37 Pain Relevance 0.03
Individuals with SWD have a significantly greater risk for morbidity (ie, ulcers and depression) than shift workers without SWD or day workers who have identical symptoms (Drake et al 2004).
SWD Binding (Individuals) of associated with depression and ulcers
3) Confidence 0.02 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761173 Disease Relevance 1.46 Pain Relevance 0.05
Modafinil may be prescribed for patients who have been evaluated for excessive sleepiness and have a diagnosis of OSA, SWD, or narcolepsy.
SWD Binding (diagnosis) of associated with apnoea and hypersomnia
4) Confidence 0.02 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761173 Disease Relevance 0.87 Pain Relevance 0.07
Patients enrolled in these studies had a diagnosis of OSA, SWD, or narcolepsy and were required to meet accepted criteria for excessive sleepiness.
SWD Binding (diagnosis) of associated with apnoea and hypersomnia
5) Confidence 0.02 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761173 Disease Relevance 1.48 Pain Relevance 0
Given the large number of individuals who work night shifts on a rotating or permanent basis or work early morning shifts (Beers 2000), recognition and diagnosis of SWD remains a pressing clinical issue.
SWD Binding (recognition) of
6) Confidence 0.02 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761173 Disease Relevance 0.18 Pain Relevance 0
By utilizing genetic markers to distinguish substrains, we determined that there was a highly significant association with SWD incidence, indicating that the locus of major effect maps to centromeric Chromosome 9 (Fig. 1), consistent with it being spkw1.
SWD Spec (determined) Binding (association) of
7) Confidence 0.01 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0.20 Pain Relevance 0.04

General Comments

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