INT234292

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Context Info
Confidence 0.71
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 2.58
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria4) plasma membrane (Gria4)
Anatomy Link Frequency
spinal 2
Gria4 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 90 99.84 Very High Very High Very High
Spinal cord 50 87.04 High High
Dorsal horn neuron 30 85.32 High High
Inflammation 45 67.32 Quite High
cerebral cortex 4 64.68 Quite High
Thalamus 13 63.84 Quite High
midbrain 2 47.44 Quite Low
Glutamate receptor 59 42.52 Quite Low
spinal dorsal horn 35 42.16 Quite Low
Lasting pain 30 33.88 Quite Low
Disease Link Frequency Relevance Heat
Nociception 130 99.92 Very High Very High Very High
Hypersensitivity 10 92.24 High High
INFLAMMATION 45 67.32 Quite High
Absence Epilepsy 15 50.00 Quite Low
Targeted Disruption 14 50.00 Quite Low
Pain 40 33.88 Quite Low
Neuropathic Pain 20 28.64 Quite Low
Inflammatory Pain 45 27.64 Quite Low
Death 1 11.60 Low Low
Dislocations 1 10.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rabbit polyclonal antibody dilutions were as follows: 1:200 for GluR3 or GluR4 carboxy terminus (Chemicon, CA); 1:5000 for Calbindin D-28 k (Swant, Switzerland); 1:1000 for ?
Phosphorylation (1:200) of GluR4
1) Confidence 0.71 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0 Pain Relevance 0.10
However, how GluR4 phosphorylation contributes to spinal nociception needs further investigation.


Phosphorylation (phosphorylation) of GluR4 in spinal associated with nociception
2) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.51 Pain Relevance 0.20
The phosphorylation of another subunit, GluR4 has also been demonstrated to play an important role in spinal nociception.
Phosphorylation (phosphorylation) of GluR4 in spinal associated with nociception
3) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.47 Pain Relevance 0.32
GluR4 is the most rapidly desensitizing subunit of AMPA receptors and is phosphorylated at Serine842, within its C-terminal domain [47].
Phosphorylation (phosphorylated) of GluR4
4) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.53 Pain Relevance 0.30
Threonine830 is also found as an important phosphorylation site on GluR4 by PKC [47].
Phosphorylation (phosphorylation) of GluR4 associated with kinase c
5) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.54 Pain Relevance 0.29
PKA, PKC, and CaMKII may phosphorylate at Serine842 site of GluR4 very well.
Phosphorylation (phosphorylate) of GluR4 associated with kinase c
6) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.54 Pain Relevance 0.29

General Comments

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