INT234293

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria4) plasma membrane (Gria4)
Anatomy Link Frequency
thalamus 2
Gria4 (Mus musculus)
Pain Link Frequency Relevance Heat
Thalamus 26 99.28 Very High Very High Very High
Glutamate 4 98.32 Very High Very High Very High
GABA receptor 2 91.32 High High
antagonist 2 90.16 High High
agonist 2 89.52 High High
cerebral cortex 8 33.44 Quite Low
Glutamate receptor 8 5.00 Very Low Very Low Very Low
Action potential 8 5.00 Very Low Very Low Very Low
midbrain 4 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 10 93.32 High High
Sprains And Strains 40 85.12 High High
Absence Epilepsy 30 80.08 Quite High
Ataxia 10 50.80 Quite High
Targeted Disruption 18 50.00 Quite Low
Epilepsy 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Generalized Epilepsy 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, in mice with greatly reduced Gria4 expression, the AMPA receptor composition would change in the reticular thalamus, resulting in the observed changes to AMPA receptor function.
Regulation (change) of Gene_expression (expression) of Gria4 in thalamus associated with thalamus
1) Confidence 0.45 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0.31 Pain Relevance 0.30
This overall effect is especially due to a decrease in the number of brief, large-amplitude events (Fig. 5C1–C3), consistent with altered GluR4 receptor expression.
Regulation (altered) of Gene_expression (expression) of GluR4 receptor
2) Confidence 0.27 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0 Pain Relevance 0.07

General Comments

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