INT234297
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
In the present study, we show that the spkw1 allele has a mutation in Gria4 leading to marked reduction in GluR4 protein expression, and we confirm the genephenotype relationship by study of Gria4 knockout mice. | |||||||||||||||
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Both RNA and protein analyses confirm that full-length Gria4 expression is significantly reduced in this strain. | |||||||||||||||
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Thus, in mice with greatly reduced Gria4 expression, the AMPA receptor composition would change in the reticular thalamus, resulting in the observed changes to AMPA receptor function. | |||||||||||||||
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During each experiment, a Gria4spkw1/+/Gria4spkw1/spkw1 pair of (FeJ×HeJ)F1×HeJ backcross mice (? | |||||||||||||||
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During each experiment, a Gria4spkw1/+/Gria4spkw1/spkw1 pair of (FeJ×HeJ)F1×HeJ backcross mice (? | |||||||||||||||
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During each experiment, a Gria4spkw1/+/Gria4spkw1/spkw1 pair of (FeJ×HeJ)F1×HeJ backcross mice (? | |||||||||||||||
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During each experiment, a Gria4spkw1/+/Gria4spkw1/spkw1 pair of (FeJ×HeJ)F1×HeJ backcross mice (? | |||||||||||||||
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During each experiment, a Gria4spkw1/+/Gria4spkw1/spkw1 pair of (FeJ×HeJ)F1×HeJ backcross mice (? | |||||||||||||||
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During each experiment, a Gria4spkw1/+/Gria4spkw1/spkw1 pair of (FeJ×HeJ)F1×HeJ backcross mice (? | |||||||||||||||
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Together these data show that a genetic deficiency in Gria4, whether reduction (Gria4spkw1 allele) or complete lack (Gria4tm1Dgen allele), is associated with a high frequency of SWD, modeling absence epilepsy. | |||||||||||||||
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General Comments
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