INT234297

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 1.49
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria4) plasma membrane (Gria4)
Anatomy Link Frequency
thalamus 2
Gria4 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 20 98.64 Very High Very High Very High
Thalamus 130 97.52 Very High Very High Very High
GABA receptor 10 91.64 High High
antagonist 10 90.48 High High
agonist 10 89.84 High High
cerebral cortex 40 80.04 Quite High
midbrain 20 23.48 Low Low
Action potential 40 22.48 Low Low
nMDA receptor 10 11.40 Low Low
Glutamate receptor 40 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 200 99.64 Very High Very High Very High
Targeted Disruption 90 97.32 Very High Very High Very High
Absence Epilepsy 150 96.20 Very High Very High Very High
Convulsion 50 93.64 High High
Infection 10 78.96 Quite High
Retina Disease 10 77.68 Quite High
Ataxia 50 55.36 Quite High
Epilepsy 20 5.00 Very Low Very Low Very Low
Congenital Anomalies 20 5.00 Very Low Very Low Very Low
Generalized Epilepsy 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we show that the spkw1 allele has a mutation in Gria4 leading to marked reduction in GluR4 protein expression, and we confirm the gene–phenotype relationship by study of Gria4 knockout mice.
Negative_regulation (reduction) of Gene_expression (expression) of GluR4 associated with targeted disruption
1) Confidence 0.59 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0.70 Pain Relevance 0.04
Both RNA and protein analyses confirm that full-length Gria4 expression is significantly reduced in this strain.
Negative_regulation (reduced) of Gene_expression (expression) of Gria4 associated with sprains and strains
2) Confidence 0.59 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0.39 Pain Relevance 0.15
Thus, in mice with greatly reduced Gria4 expression, the AMPA receptor composition would change in the reticular thalamus, resulting in the observed changes to AMPA receptor function.
Negative_regulation (reduced) of Gene_expression (expression) of Gria4 in thalamus associated with thalamus
3) Confidence 0.59 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0.31 Pain Relevance 0.30
During each experiment, a Gria4spkw1/+/Gria4spkw1/spkw1 pair of (FeJ×HeJ)F1×HeJ backcross mice (?
Negative_regulation (backcross) of Gene_expression (pair) of Gria4spkw1
4) Confidence 0.43 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0 Pain Relevance 0
During each experiment, a Gria4spkw1/+/Gria4spkw1/spkw1 pair of (FeJ×HeJ)F1×HeJ backcross mice (?
Negative_regulation (/) of Gene_expression (pair) of spkw1
5) Confidence 0.43 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0 Pain Relevance 0
During each experiment, a Gria4spkw1/+/Gria4spkw1/spkw1 pair of (FeJ×HeJ)F1×HeJ backcross mice (?
Negative_regulation (/) of Gene_expression (pair) of Gria4spkw1
6) Confidence 0.43 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0 Pain Relevance 0
During each experiment, a Gria4spkw1/+/Gria4spkw1/spkw1 pair of (FeJ×HeJ)F1×HeJ backcross mice (?
Negative_regulation (/) of Gene_expression (pair) of Gria4spkw1
7) Confidence 0.43 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0 Pain Relevance 0
During each experiment, a Gria4spkw1/+/Gria4spkw1/spkw1 pair of (FeJ×HeJ)F1×HeJ backcross mice (?
Negative_regulation (backcross) of Gene_expression (pair) of Gria4spkw1
8) Confidence 0.43 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0 Pain Relevance 0
During each experiment, a Gria4spkw1/+/Gria4spkw1/spkw1 pair of (FeJ×HeJ)F1×HeJ backcross mice (?
Negative_regulation (backcross) of Gene_expression (pair) of spkw1
9) Confidence 0.43 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0 Pain Relevance 0
Together these data show that a genetic deficiency in Gria4, whether reduction (Gria4spkw1 allele) or complete lack (Gria4tm1Dgen allele), is associated with a high frequency of SWD, modeling absence epilepsy.
Spec (whether) Negative_regulation (reduction) of Gene_expression (allele) of Gria4spkw1 associated with absence epilepsy
10) Confidence 0.37 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0.10 Pain Relevance 0

General Comments

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