INT234300

Context Info Confidence 0.39 First Reported 2008 Last Reported 2008 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0.05

transport (Gria4) plasma membrane (Gria4)

Anatomy Link Frequency neurons 1 Gria4 (Mus musculus)

Pain Link Frequency Relevance Heat Thalamus 13 98.56 cerebral cortex 4 5.00 Glutamate receptor 4 5.00 Action potential 4 5.00 midbrain 2 5.00 Glutamate 2 5.00 tetrodotoxin 1 5.00 Analgesic 1 5.00 GABA receptor 1 5.00 sodium channel 1 5.00

Disease Link Frequency Relevance Heat Ataxia 5 69.12 Absence Epilepsy 15 50.00 Targeted Disruption 9 50.00 Sprains And Strains 20 5.00 Convulsion 5 5.00 Epilepsy 2 5.00 Congenital Anomalies 2 5.00 Generalized Epilepsy 2 5.00 Death 1 5.00 Dislocations 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To initially determine whether the Gria4spkw1 mutation affected the synaptic activity of reticular thalamus inhibitory neurons, we examined spontaneous excitatory postsynaptic currents (sEPSCs, see Materials and Methods) of Gria4spkw1 homozygous intra-C3H backcross mice with very high incidence of SWD and of heterozygous littermate control mice.

Spec (whether) Regulation (affected) of Gria4spkw1 in neurons associated with thalamus

1) Confidence 0.39 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0.07 Pain Relevance 0.05

General Comments

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