INT234303

Context Info Confidence 0.36 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.16

transport (Gria3, Gria4) plasma membrane (Gria3, Gria4) protein complex (Gria3)

Anatomy Link Frequency thalamus 1 Gria3 (Mus musculus) Gria4 (Mus musculus)

Pain Link Frequency Relevance Heat Thalamus 13 99.96 cerebral cortex 4 58.80 Glutamate receptor 4 5.00 Action potential 4 5.00 midbrain 2 5.00 Glutamate 2 5.00 tetrodotoxin 1 5.00 Analgesic 1 5.00 GABA receptor 1 5.00 sodium channel 1 5.00

Disease Link Frequency Relevance Heat Absence Epilepsy 15 50.00 Targeted Disruption 9 50.00 Sprains And Strains 20 48.40 Ataxia 5 21.04 Convulsion 5 5.00 Epilepsy 2 5.00 Congenital Anomalies 2 5.00 Generalized Epilepsy 2 5.00 Death 1 5.00 Dislocations 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As GluR4 containing AMPA receptors express fast decay kinetics, e.g. compared with the other subunit expressed in the reticular thalamus, GluR3 (22,23), then loss of GluR4 would be expected to increase the duration of the excitatory synaptic responses, consistent with our observations.

GluR3 Negative_regulation (loss) of GluR4 in thalamus associated with thalamus

1) Confidence 0.36 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0 Pain Relevance 0.16

General Comments

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