INT23435

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 54
Total Number 54
Disease Relevance 32.41
Pain Relevance 30.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NGF) signal transduction (NGF) extracellular space (NGF)
extracellular region (NGF)
Anatomy Link Frequency
nerve 8
brain 3
ciliary 2
central nervous system 2
skin 2
NGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 737 100.00 Very High Very High Very High
substance P 122 100.00 Very High Very High Very High
Glutamate 18 100.00 Very High Very High Very High
bradykinin 14 100.00 Very High Very High Very High
Inflammatory mediators 5 100.00 Very High Very High Very High
Pain 570 99.84 Very High Very High Very High
Inflammation 194 99.84 Very High Very High Very High
Osteoarthritis 16 99.76 Very High Very High Very High
Central nervous system 18 99.72 Very High Very High Very High
IPN 11 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 199 100.00 Very High Very High Very High
Nociception 105 100.00 Very High Very High Very High
Pain 549 99.84 Very High Very High Very High
Osteoarthritis 25 99.76 Very High Very High Very High
Inflammatory Pain 19 99.64 Very High Very High Very High
Neuropathic Pain 78 99.62 Very High Very High Very High
Hyperalgesia 79 99.34 Very High Very High Very High
Hepatocellular Cancer 76 99.00 Very High Very High Very High
Endometriosis 224 98.60 Very High Very High Very High
Colon Cancer 3 98.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While NGF levels are acutely reduced in injured nerve trunks, neuropathic patients with chronic skin hyperalgesia and allodynia show marked local increases of NGF levels; here anti-NGF agents may provide analgesia.
Positive_regulation (increases) of NGF in skin associated with hyperalgesia, allodynia, nerve growth factor, neuropathic pain and analgesia
1) Confidence 0.70 Published 2004 Journal Prog. Brain Res. Section Abstract Doc Link 14699981 Disease Relevance 0.99 Pain Relevance 1.24
In concert with this protection, there is an upregulation of neurotrophins [i.e., nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF)].
Positive_regulation (upregulation) of nerve growth factor in brain associated with nerve growth factor
2) Confidence 0.70 Published 2008 Journal J. Alzheimers Dis. Section Abstract Doc Link 18997293 Disease Relevance 0.36 Pain Relevance 0.40
In concert with this protection, there is an upregulation of neurotrophins [i.e., nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF)].
Positive_regulation (upregulation) of NGF in brain associated with nerve growth factor
3) Confidence 0.70 Published 2008 Journal J. Alzheimers Dis. Section Abstract Doc Link 18997293 Disease Relevance 0.36 Pain Relevance 0.40
In a wide variety of experimental inflammatory conditions NGF levels are rapidly increased in the inflamed tissue. 3.
Positive_regulation (increased) of NGF associated with nerve growth factor and inflammation
4) Confidence 0.70 Published 1996 Journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 8730782 Disease Relevance 0.72 Pain Relevance 1.00
The mechanisms by which NGF up-regulation in inflamed tissues might lead to sensory abnormalities is also discussed.
Positive_regulation (up-regulation) of NGF associated with nerve growth factor and congenital anomalies
5) Confidence 0.70 Published 1996 Journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 8730782 Disease Relevance 0.79 Pain Relevance 1.23
In particular, evidence is reviewed which suggests that increased NGF levels leads to both peripheral sensitization of nociceptors and central sensitization of dorsal horn neurons responding to noxious stimuli.
Positive_regulation (increased) of NGF in neurons associated with central sensitization, nerve growth factor, nociceptor, peripheral sensitization and dorsal horn neuron
6) Confidence 0.70 Published 1996 Journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 8730782 Disease Relevance 0.74 Pain Relevance 1.17
Citric acid perfusion marginally increased NGF levels to 7.3 fg/microg/ml on average in the upper arm and control axilla.
Positive_regulation (increased) of NGF in axilla associated with nerve growth factor
7) Confidence 0.69 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18571954 Disease Relevance 0.32 Pain Relevance 0.59
NGF is upregulated in a wide variety of inflammatory conditions, and NGF-neutralizing molecules are effective analgesic agents in many models of persistent pain.
Positive_regulation (upregulated) of NGF associated with pain, inflammation, nerve growth factor, lasting pain and analgesic
8) Confidence 0.69 Published 2006 Journal Annu. Rev. Neurosci. Section Abstract Doc Link 16776595 Disease Relevance 0.53 Pain Relevance 0.97
RESULTS: Northern blot analysis indicated that NGF and TrkA mRNA levels were increased 2.7-fold and 5.6-fold, respectively (P <.05 and P <.05), in pancreatic cancer tissues compared with the normal pancreas tissue.
Positive_regulation (increased) of NGF in pancreas
9) Confidence 0.69 Published 1999 Journal J. Clin. Oncol. Section Body Doc Link 10561305 Disease Relevance 0.17 Pain Relevance 0
The level of peripheral NGF is increased in inflammatory processes, while the administration of exogenous NGF has a hyperalgesic effect on rats and produces muscular pain in humans.
Positive_regulation (increased) of NGF associated with pain, hyperalgesia and inflammation
10) Confidence 0.68 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19399531 Disease Relevance 0.51 Pain Relevance 0.32
We recently found that the activated nerve growth factor (NGF) receptor p-TrkA is more frequently expressed compared to p75, another NGF receptor that belongs to the tumor necrosis factor family, in MM, and that p-TrkA expression is significantly higher in peritoneal MM compared to their pleural counterparts (Figures 1-D, 1-E).
Positive_regulation (activated) of NGF in nerve associated with necrosis, lung cancer, nerve growth factor and cancer
11) Confidence 0.67 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 0.95 Pain Relevance 0.15
Studies investigating a role for neurotrophins in the pathogenesis of osteoarthritis have shown upregulation of both NGF and Trk-A in osteoarthritic chondrocytes [15].
Positive_regulation (upregulation) of NGF in chondrocytes associated with nerve growth factor and osteoarthritis
12) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.37 Pain Relevance 0.43
in the stimulation of NGF from fibroblasts [36], and therefore whether the effects of TNF?
Positive_regulation (stimulation) of NGF in fibroblasts associated with nerve growth factor
13) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.51 Pain Relevance 0.48
Whether both NGF and BDNF are upregulated in the degenerate IVD, and as such play a key role in innervation and the pathogenesis of low back pain, however, remains to be determined.
Positive_regulation (upregulated) of NGF associated with low back pain, nerve growth factor and backache
14) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.21 Pain Relevance 0.45
Studies by Kemi and colleagues have demonstrated upregulation of NGF and BDNF in bronchial smooth muscle cells after treatment with IL-1 [26].
Positive_regulation (upregulation) of NGF in smooth muscle cells associated with nerve growth factor
15) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.40 Pain Relevance 0.46
Using a rat model of experimental IVD herniation, Onda and colleagues have highlighted a correlation between induction of NGF within the dorsal nerve root using surgical procedures and pain behaviour [31].
Positive_regulation (induction) of NGF in dorsal nerve associated with pain and nerve growth factor
16) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.50 Pain Relevance 0.88
Estrogens upregulate NGF receptor mRNA in sensory neurons [10], and enhance the proliferative effects of NGF [11,12].
Positive_regulation (upregulate) of NGF in sensory neurons associated with nerve growth factor
17) Confidence 0.62 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC554997 Disease Relevance 1.36 Pain Relevance 1.39
As NGF is a key molecule that determines the sensitivity of nociceptors in humans [13] and animal models [14], sex hormonal influences could be responsible for altered NGF activity during the menstrual cycle, leading to cyclical breast soreness or pain.
Positive_regulation (responsible) of NGF in nociceptors associated with pain, nerve growth factor and nociceptor
18) Confidence 0.62 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC554997 Disease Relevance 1.43 Pain Relevance 1.51
Mutations of the NGF high-affinity receptor tyrosine kinase A (Trk A) have been found in congenital insensitivity to pain and anhidrosis; these are likely to be partial loss-of-function mutations, as axon-reflex vasodilatation and sweating can be elicited albeit reduced, suggesting rhNGF could restore nociception in some patients.
Positive_regulation (high-affinity) of NGF associated with nociception, hypohidrosis, pain, congenital analgesia, nerve growth factor, trk a and increased venous pressure under development
19) Confidence 0.50 Published 2004 Journal Prog. Brain Res. Section Abstract Doc Link 14699981 Disease Relevance 0.98 Pain Relevance 0.60
The time course of pressure allodynia and heat-pain hyperalgesia is too rapid to be explained by uptake of NGF by nociception terminals, retrograde transport, and upregulation of pain modulators.
Positive_regulation (upregulation) of NGF associated with nociception, pain, hyperalgesia, nerve growth factor and allodynia
20) Confidence 0.50 Published 1997 Journal Neurology Section Abstract Doc Link 9040746 Disease Relevance 1.11 Pain Relevance 1.33

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